Re: Magnesium & Diabetes?

Kumar wrote:
> Andrew B. Chung, MD/PhD wrote:
> > Convicted neighbor Kumar wrote:
> > > Andrew B. Chung, MD/PhD wrote:
> > > > Convicted neighbor Kumar wrote:
> > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > Convicted neighbor Kumar wrote:
> > > > > > > Hello,
> > > > > > > **Happy New Year**
> > > > > > >
> > > > > > > "Magnesium is an essential mineral to the human body. It is needed for
> > > > > > > bone, protein, and fatty acid formation, making new cells, activating B
> > > > > > > vitamins, relaxing muscles, clotting blood, and forming adenosine
> > > > > > > triphosphate (ATP; the energy the body runs on). **The secretion and
> > > > > > > action of insulin also require magnesium.
> > > > > > >
> > > > > > > Where is it found?
> > > > > > > Nuts and grains are good sources of magnesium. Beans, dark green
> > > > > > > vegetables, fish, and meat also contain significant amounts.
> > > > > > >
> > > > > > > Vitamin B6 increases the amount of magnesium that can enter cells. As a
> > > > > > > result, these two nutrients are often taken together. Magnesium may
> > > > > > > compete for absorption with other minerals, particularly calcium.
> > > > > > > http://www.vitacost.com/Healthnotes/Supp/Magnesium.aspx "
> > > > > > >
> > > > > > > Many sites link Magnesium defficiencies with diabetes2.
> > > > > > >
> > > > > > > Can you guide how Magnesium is related to hyperglycemia, insulin
> > > > > > > resistance..diabetes2?
> > > > > > >
> > > > > > > As such, whether Vit.B6, Sodium, Potassium and Calcium instabilities
> > > > > > > can also be related?
> > > > > >
> > > > > > Nutritional deficiencies simply do not occur when there is overeating:
> > > > >
> > > > > "Eating Whole Grains, Nuts and Green Leafy Veggies May Help Ward Off
> > > > > Type 2
> > > > > -- Other Studies Show Weight-Loss Drug May Help Prevent Diabetes
> > > > > Complications; ADA/AHA Statement Guiding Doctors on Use of TZDs
> > > > >
> > > > > (Alexandria, VA) - Two studies in the January issue of Diabetes Care
> > > > > add weight to a growing body of evidence that a diet high in magnesium
> > > > > may help prevent the development of type 2 diabetes, especially in
> > > > > people who are overweight.
> > > > >
> > > > > Also in this month's journal: Two studies find additional benefits
> > > > > to the weight-loss drug Orlistat, which researchers now believe may
> > > > > lower free fatty acid levels, improve insulin sensitivity and lower the
> > > > > chance of developing type 2 diabetes among people whose glucose
> > > > > tolerance is already impaired; and a joint American Diabetes
> > > > > Association/American Heart Association consensus statement provides
> > > > > guidance to physicians in the use of glucose-lowering agents known as
> > > > > thiazolidinediones (TZDs).
> > > > > http://www.diabetes.org/for-media/di...e/12-23-03.jsp "
> > > > >
> > > > >
> > > > > " Dietary magnesium lowers diabetes risk
> > > > >
> > > > >
> > > > > Research suggests that nuts, grains, leafy green vegetables and other
> > > > > foods high in magnesium may keep diabetes at bay. In recent studies,
> > > > > people who consumed high magnesium diets were less likely to develop
> > > > > type 2 diabetes.
> > > > >
> > > > > Until now, very few large studies have directly examined the long-term
> > > > > effects of dietary magnesium on diabetes. Researchers at the Harvard
> > > > > Medical School and School of Public Health in Boston provided some
> > > > > direct evidence in their studies, that greater intake of dietary
> > > > > magnesium may have a long-term protective effect on lowering diabetes
> > > > > risk.
> > > > >
> > > > > In one of the studies, researchers evaluated the nutrition of about
> > > > > 85,000 female nurses and more than 42,000 male health professionals
> > > > > every 2 to 4 years. Women were followed for 18 years and the men for 12
> > > > > years. In both men and women, those who consumed the most magnesium in
> > > > > their diet were least likely to develop type 2 diabetes during the
> > > > > study. This risk reduction was still present even after researchers
> > > > > adjusted for factors that could have influenced the results, including
> > > > > age, total caloric intake, family history of diabetes, physical
> > > > > activity and alcohol consumption. Body mass index (BMI), did have some
> > > > > effect, but the link between magnesium and a lower risk of diabetes was
> > > > > still significant. Most of the participants got their magnesium from
> > > > > food, and not vitamin supplements.
> > > > >
> > > > > The second study involved more than 39,000 women who had no history of
> > > > > diabetes, heart disease or cancer. The women were followed for 6 years
> > > > > to see if the amount of magnesium they consumed affected the odds of
> > > > > developing diabetes. They found that women who consumed more magnesium
> > > > > in their diet were less likely to develop diabetes. But the link
> > > > > between magnesium and diabetes risk was seen only in women who had a
> > > > > BMI of 25 or higher. Individuals with a BMI of 25 to 29.9 are
> > > > > considered overweight, while those with a BMI of 30 or higher are
> > > > > considered obese.
> > > > >
> > > > > The next step would be a randomised prospective clinical trial to test
> > > > > the effect of consuming major food sources of magnesium, on the
> > > > > development of type 2 diabetes in a high-risk population. In the
> > > > > meantime, a diet rich in plant-based foods that are high in magnesium
> > > > > may be beneficial for preventing diabetes.
> > > > > http://www.doctorndtv.com/news/detailnews.asp?id=754 "
> > > > >
> > > > > Many sites indicate Mg defficiencies are common and its great link with
> > > > > diabetes, obesity, HBP etc.
> > > >
> > > > There are folks who are selling magnesium to make money.
> >
> > > It is one of the important mineral.
> >
> > It is ubiquitously found in the soil and in the foods we eat.
>
> "Hypomagnesemia is an electrolyte disturbance in which there is an
> abnormally low level of magnesium in the blood. Usually a serum level
> less than 0.6 mmol/l is used as reference. **It must be noted that
> hypomagnesemia is not equal to magnesium deficiency. Hypomagnesemia can
> be present without magnesium deficiency and vice versa...
> Magnesium deficiency is not uncommon in hospitalized patients. Elevated
> levels of magnesium (hypermagnesemia), however, are nearly always
> iatrogenic. 10-20% of all hospital patients, and 60-65% of patient in
> the intensive care unit (ICU) have hypomagnesemia. **Hypomagnesiemia is
> underdiagnosed, as testing for serum magnesium levels is not routine.
> Hypomagnesemia results in increased mortality
> http://en.wikipedia.org/wiki/Hypomagnesemia "
>
> It can be very important as;
>
> "Electrolyte disturbances
> Hypokalemia: 42% of patients with hypokalemia also have hypomagnesemia,
> not responding to potassium supplementation. Magnesium is needed for
> the ATPase, Na-K-pump.
> Hypocalcemia is present in 33% of patients in the intensive care unit,
> not responding to calcium supplementation. This is because of decreased
> function of the calcium pump, but also because of a decreased release
> of calcium by inhibition of parathyroid hormone release.
> http://en.wikipedia.org/wiki/Hypomagnesemia"

Note that what you cite does not support a connection between
hypomagnesemia and diabetes.

Andrew B. Chung, MD/PhD wrote:
> Kumar wrote:
> > Andrew B. Chung, MD/PhD wrote:
> > > Convicted neighbor Kumar wrote:
> > > > Andrew B. Chung, MD/PhD wrote:
> > > > > Convicted neighbor Kumar wrote:
> > > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > > Convicted neighbor Kumar wrote:
> > > > > > > > Hello,
> > > > > > > > **Happy New Year**
> > > > > > > >
> > > > > > > > "Magnesium is an essential mineral to the human body. It is needed for
> > > > > > > > bone, protein, and fatty acid formation, making new cells, activating B
> > > > > > > > vitamins, relaxing muscles, clotting blood, and forming adenosine
> > > > > > > > triphosphate (ATP; the energy the body runs on). **The secretion and
> > > > > > > > action of insulin also require magnesium.
> > > > > > > >
> > > > > > > > Where is it found?
> > > > > > > > Nuts and grains are good sources of magnesium. Beans, dark green
> > > > > > > > vegetables, fish, and meat also contain significant amounts.
> > > > > > > >
> > > > > > > > Vitamin B6 increases the amount of magnesium that can enter cells. As a
> > > > > > > > result, these two nutrients are often taken together. Magnesium may
> > > > > > > > compete for absorption with other minerals, particularly calcium.
> > > > > > > > http://www.vitacost.com/Healthnotes/Supp/Magnesium.aspx "
> > > > > > > >
> > > > > > > > Many sites link Magnesium defficiencies with diabetes2.
> > > > > > > >
> > > > > > > > Can you guide how Magnesium is related to hyperglycemia, insulin
> > > > > > > > resistance..diabetes2?
> > > > > > > >
> > > > > > > > As such, whether Vit.B6, Sodium, Potassium and Calcium instabilities
> > > > > > > > can also be related?
> > > > > > >
> > > > > > > Nutritional deficiencies simply do not occur when there is overeating:
> > > > > >
> > > > > > "Eating Whole Grains, Nuts and Green Leafy Veggies May Help Ward Off
> > > > > > Type 2
> > > > > > -- Other Studies Show Weight-Loss Drug May Help Prevent Diabetes
> > > > > > Complications; ADA/AHA Statement Guiding Doctors on Use of TZDs
> > > > > >
> > > > > > (Alexandria, VA) - Two studies in the January issue of Diabetes Care
> > > > > > add weight to a growing body of evidence that a diet high in magnesium
> > > > > > may help prevent the development of type 2 diabetes, especially in
> > > > > > people who are overweight.
> > > > > >
> > > > > > Also in this month's journal: Two studies find additional benefits
> > > > > > to the weight-loss drug Orlistat, which researchers now believe may
> > > > > > lower free fatty acid levels, improve insulin sensitivity and lower the
> > > > > > chance of developing type 2 diabetes among people whose glucose
> > > > > > tolerance is already impaired; and a joint American Diabetes
> > > > > > Association/American Heart Association consensus statement provides
> > > > > > guidance to physicians in the use of glucose-lowering agents known as
> > > > > > thiazolidinediones (TZDs).
> > > > > > http://www.diabetes.org/for-media/di...e/12-23-03.jsp "
> > > > > >
> > > > > >
> > > > > > " Dietary magnesium lowers diabetes risk
> > > > > >
> > > > > >
> > > > > > Research suggests that nuts, grains, leafy green vegetables and other
> > > > > > foods high in magnesium may keep diabetes at bay. In recent studies,
> > > > > > people who consumed high magnesium diets were less likely to develop
> > > > > > type 2 diabetes.
> > > > > >
> > > > > > Until now, very few large studies have directly examined the long-term
> > > > > > effects of dietary magnesium on diabetes. Researchers at the Harvard
> > > > > > Medical School and School of Public Health in Boston provided some
> > > > > > direct evidence in their studies, that greater intake of dietary
> > > > > > magnesium may have a long-term protective effect on lowering diabetes
> > > > > > risk.
> > > > > >
> > > > > > In one of the studies, researchers evaluated the nutrition of about
> > > > > > 85,000 female nurses and more than 42,000 male health professionals
> > > > > > every 2 to 4 years. Women were followed for 18 years and the men for 12
> > > > > > years. In both men and women, those who consumed the most magnesium in
> > > > > > their diet were least likely to develop type 2 diabetes during the
> > > > > > study. This risk reduction was still present even after researchers
> > > > > > adjusted for factors that could have influenced the results, including
> > > > > > age, total caloric intake, family history of diabetes, physical
> > > > > > activity and alcohol consumption. Body mass index (BMI), did have some
> > > > > > effect, but the link between magnesium and a lower risk of diabetes was
> > > > > > still significant. Most of the participants got their magnesium from
> > > > > > food, and not vitamin supplements.
> > > > > >
> > > > > > The second study involved more than 39,000 women who had no history of
> > > > > > diabetes, heart disease or cancer. The women were followed for 6 years
> > > > > > to see if the amount of magnesium they consumed affected the odds of
> > > > > > developing diabetes. They found that women who consumed more magnesium
> > > > > > in their diet were less likely to develop diabetes. But the link
> > > > > > between magnesium and diabetes risk was seen only in women who had a
> > > > > > BMI of 25 or higher. Individuals with a BMI of 25 to 29.9 are
> > > > > > considered overweight, while those with a BMI of 30 or higher are
> > > > > > considered obese.
> > > > > >
> > > > > > The next step would be a randomised prospective clinical trial to test
> > > > > > the effect of consuming major food sources of magnesium, on the
> > > > > > development of type 2 diabetes in a high-risk population. In the
> > > > > > meantime, a diet rich in plant-based foods that are high in magnesium
> > > > > > may be beneficial for preventing diabetes.
> > > > > > http://www.doctorndtv.com/news/detailnews.asp?id=754 "
> > > > > >
> > > > > > Many sites indicate Mg defficiencies are common and its great link with
> > > > > > diabetes, obesity, HBP etc.
> > > > >
> > > > > There are folks who are selling magnesium to make money.
> > >
> > > > It is one of the important mineral.
> > >
> > > It is ubiquitously found in the soil and in the foods we eat.
> >
> > "Hypomagnesemia is an electrolyte disturbance in which there is an
> > abnormally low level of magnesium in the blood. Usually a serum level
> > less than 0.6 mmol/l is used as reference. **It must be noted that
> > hypomagnesemia is not equal to magnesium deficiency. Hypomagnesemia can
> > be present without magnesium deficiency and vice versa...
> > Magnesium deficiency is not uncommon in hospitalized patients. Elevated
> > levels of magnesium (hypermagnesemia), however, are nearly always
> > iatrogenic. 10-20% of all hospital patients, and 60-65% of patient in
> > the intensive care unit (ICU) have hypomagnesemia. **Hypomagnesiemia is
> > underdiagnosed, as testing for serum magnesium levels is not routine.
> > Hypomagnesemia results in increased mortality
> > http://en.wikipedia.org/wiki/Hypomagnesemia "
> >
> > It can be very important as;
> >
> > "Electrolyte disturbances
> > Hypokalemia: 42% of patients with hypokalemia also have hypomagnesemia,
> > not responding to potassium supplementation. Magnesium is needed for
> > the ATPase, Na-K-pump.
> > Hypocalcemia is present in 33% of patients in the intensive care unit,
> > not responding to calcium supplementation. This is because of decreased
> > function of the calcium pump, but also because of a decreased release
> > of calcium by inhibition of parathyroid hormone release.
> > http://en.wikipedia.org/wiki/Hypomagnesemia"
>
> Note that what you cite does not support a connection between
> hypomagnesemia and diabetes.

Following quote can indicate it;

"Magnesium needs in the American population
The Recommended Daily Allowance (RDA) for magnesium is 6 mg/kg/d. This
means 400 mg/d to 420 mg/d for adult men and 320 mg/d for adult women
(and even more for women who are pregnant or lactating). By these
standards, which have been promulgated by the National Academy of
Sciences and the Institute of Medicine after great deliberation,
research, and literature review, an estimated 50% to 85% of the
population of the United States is receiving an inadequate magnesium
intake.

Levels of magnesium may be particularly low in certain populations,
such as African Americans. For example, the prevalence of
hypomagnesemia is 20% among urban African Americans in the city of
Buffalo, NY, and surrounding area. This exceeds the prevalence of
hypomagnesemia in the general population, and implies a risk for
diabetes, hyperlipidemia, hypertension, other cardiovascular disease,
and renal disease. Low dietary magnesium intake is correlated with
insulin resistance in non-elderly African Americans without diabetes.

The American Diabetes Association (ADA) recognizes the increased risks
associated with magnesium deficiency in patients with certain diseases
or conditions (Table 1). In addition, the ADA recommends that magnesium
levels be measured in such patients and repleted if deficient.

Magnesium levels in patients with diabetes
Many studies have shown that both mean plasma and intracellular free
magnesium levels are lower in patients with diabetes than in the
general population. This magnesium deficiency, which may take the form
of a chronic latent magnesium deficit rather than clinical
hypomagnesemia, may have clinical importance because the magnesium ion
is a crucial cofactor for many enzymatic reactions involved in
metabolic processes.
http://www.mgwater.com/diabetes.shtml "

Convicted neighbor Kumar wrote:
> Andrew, in the Holy Spirit, boldly wrote:
> > Convicted neighbor Kumar wrote:
> > > Andrew B. Chung, MD/PhD wrote:
> > > > Convicted neighbor Kumar wrote:
> > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > Convicted neighbor Kumar wrote:
> > > > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > > > Convicted neighbor Kumar wrote:
> > > > > > > > > Hello,
> > > > > > > > > **Happy New Year**
> > > > > > > > >
> > > > > > > > > "Magnesium is an essential mineral to the human body. It is needed for
> > > > > > > > > bone, protein, and fatty acid formation, making new cells, activating B
> > > > > > > > > vitamins, relaxing muscles, clotting blood, and forming adenosine
> > > > > > > > > triphosphate (ATP; the energy the body runs on). **The secretion and
> > > > > > > > > action of insulin also require magnesium.
> > > > > > > > >
> > > > > > > > > Where is it found?
> > > > > > > > > Nuts and grains are good sources of magnesium. Beans, dark green
> > > > > > > > > vegetables, fish, and meat also contain significant amounts.
> > > > > > > > >
> > > > > > > > > Vitamin B6 increases the amount of magnesium that can enter cells. As a
> > > > > > > > > result, these two nutrients are often taken together. Magnesium may
> > > > > > > > > compete for absorption with other minerals, particularly calcium.
> > > > > > > > > http://www.vitacost.com/Healthnotes/Supp/Magnesium.aspx "
> > > > > > > > >
> > > > > > > > > Many sites link Magnesium defficiencies with diabetes2.
> > > > > > > > >
> > > > > > > > > Can you guide how Magnesium is related to hyperglycemia, insulin
> > > > > > > > > resistance..diabetes2?
> > > > > > > > >
> > > > > > > > > As such, whether Vit.B6, Sodium, Potassium and Calcium instabilities
> > > > > > > > > can also be related?
> > > > > > > >
> > > > > > > > Nutritional deficiencies simply do not occur when there is overeating:
> > > > > > >
> > > > > > > "Eating Whole Grains, Nuts and Green Leafy Veggies May Help Ward Off
> > > > > > > Type 2
> > > > > > > -- Other Studies Show Weight-Loss Drug May Help Prevent Diabetes
> > > > > > > Complications; ADA/AHA Statement Guiding Doctors on Use of TZDs
> > > > > > >
> > > > > > > (Alexandria, VA) - Two studies in the January issue of Diabetes Care
> > > > > > > add weight to a growing body of evidence that a diet high in magnesium
> > > > > > > may help prevent the development of type 2 diabetes, especially in
> > > > > > > people who are overweight.
> > > > > > >
> > > > > > > Also in this month's journal: Two studies find additional benefits
> > > > > > > to the weight-loss drug Orlistat, which researchers now believe may
> > > > > > > lower free fatty acid levels, improve insulin sensitivity and lower the
> > > > > > > chance of developing type 2 diabetes among people whose glucose
> > > > > > > tolerance is already impaired; and a joint American Diabetes
> > > > > > > Association/American Heart Association consensus statement provides
> > > > > > > guidance to physicians in the use of glucose-lowering agents known as
> > > > > > > thiazolidinediones (TZDs).
> > > > > > > http://www.diabetes.org/for-media/di...e/12-23-03.jsp "
> > > > > > >
> > > > > > >
> > > > > > > " Dietary magnesium lowers diabetes risk
> > > > > > >
> > > > > > >
> > > > > > > Research suggests that nuts, grains, leafy green vegetables and other
> > > > > > > foods high in magnesium may keep diabetes at bay. In recent studies,
> > > > > > > people who consumed high magnesium diets were less likely to develop
> > > > > > > type 2 diabetes.
> > > > > > >
> > > > > > > Until now, very few large studies have directly examined the long-term
> > > > > > > effects of dietary magnesium on diabetes. Researchers at the Harvard
> > > > > > > Medical School and School of Public Health in Boston provided some
> > > > > > > direct evidence in their studies, that greater intake of dietary
> > > > > > > magnesium may have a long-term protective effect on lowering diabetes
> > > > > > > risk.
> > > > > > >
> > > > > > > In one of the studies, researchers evaluated the nutrition of about
> > > > > > > 85,000 female nurses and more than 42,000 male health professionals
> > > > > > > every 2 to 4 years. Women were followed for 18 years and the men for 12
> > > > > > > years. In both men and women, those who consumed the most magnesium in
> > > > > > > their diet were least likely to develop type 2 diabetes during the
> > > > > > > study. This risk reduction was still present even after researchers
> > > > > > > adjusted for factors that could have influenced the results, including
> > > > > > > age, total caloric intake, family history of diabetes, physical
> > > > > > > activity and alcohol consumption. Body mass index (BMI), did have some
> > > > > > > effect, but the link between magnesium and a lower risk of diabetes was
> > > > > > > still significant. Most of the participants got their magnesium from
> > > > > > > food, and not vitamin supplements.
> > > > > > >
> > > > > > > The second study involved more than 39,000 women who had no history of
> > > > > > > diabetes, heart disease or cancer. The women were followed for 6 years
> > > > > > > to see if the amount of magnesium they consumed affected the odds of
> > > > > > > developing diabetes. They found that women who consumed more magnesium
> > > > > > > in their diet were less likely to develop diabetes. But the link
> > > > > > > between magnesium and diabetes risk was seen only in women who had a
> > > > > > > BMI of 25 or higher. Individuals with a BMI of 25 to 29.9 are
> > > > > > > considered overweight, while those with a BMI of 30 or higher are
> > > > > > > considered obese.
> > > > > > >
> > > > > > > The next step would be a randomised prospective clinical trial to test
> > > > > > > the effect of consuming major food sources of magnesium, on the
> > > > > > > development of type 2 diabetes in a high-risk population. In the
> > > > > > > meantime, a diet rich in plant-based foods that are high in magnesium
> > > > > > > may be beneficial for preventing diabetes.
> > > > > > > http://www.doctorndtv.com/news/detailnews.asp?id=754 "
> > > > > > >
> > > > > > > Many sites indicate Mg defficiencies are common and its great link with
> > > > > > > diabetes, obesity, HBP etc.
> > > > > >
> > > > > > There are folks who are selling magnesium to make money.
> > > >
> > > > > It is one of the important mineral.
> > > >
> > > > It is ubiquitously found in the soil and in the foods we eat.
> > >
> > > "Hypomagnesemia is an electrolyte disturbance in which there is an
> > > abnormally low level of magnesium in the blood. Usually a serum level
> > > less than 0.6 mmol/l is used as reference. **It must be noted that
> > > hypomagnesemia is not equal to magnesium deficiency. Hypomagnesemia can
> > > be present without magnesium deficiency and vice versa...
> > > Magnesium deficiency is not uncommon in hospitalized patients. Elevated
> > > levels of magnesium (hypermagnesemia), however, are nearly always
> > > iatrogenic. 10-20% of all hospital patients, and 60-65% of patient in
> > > the intensive care unit (ICU) have hypomagnesemia. **Hypomagnesiemia is
> > > underdiagnosed, as testing for serum magnesium levels is not routine.
> > > Hypomagnesemia results in increased mortality
> > > http://en.wikipedia.org/wiki/Hypomagnesemia "
> > >
> > > It can be very important as;
> > >
> > > "Electrolyte disturbances
> > > Hypokalemia: 42% of patients with hypokalemia also have hypomagnesemia,
> > > not responding to potassium supplementation. Magnesium is needed for
> > > the ATPase, Na-K-pump.
> > > Hypocalcemia is present in 33% of patients in the intensive care unit,
> > > not responding to calcium supplementation. This is because of decreased
> > > function of the calcium pump, but also because of a decreased release
> > > of calcium by inhibition of parathyroid hormone release.
> > > http://en.wikipedia.org/wiki/Hypomagnesemia"
> >
> > Note that what you cite does not support a connection between
> > hypomagnesemia and diabetes.
>
> Following quote can indicate it;
>
> "Magnesium needs in the American population
> The Recommended Daily Allowance (RDA) for magnesium is 6 mg/kg/d. This
> means 400 mg/d to 420 mg/d for adult men and 320 mg/d for adult women
> (and even more for women who are pregnant or lactating). By these
> standards, which have been promulgated by the National Academy of
> Sciences and the Institute of Medicine after great deliberation,
> research, and literature review, an estimated 50% to 85% of the
> population of the United States is receiving an inadequate magnesium
> intake.
>
> Levels of magnesium may be particularly low in certain populations,
> such as African Americans. For example, the prevalence of
> hypomagnesemia is 20% among urban African Americans in the city of
> Buffalo, NY, and surrounding area. This exceeds the prevalence of
> hypomagnesemia in the general population, and implies a risk for
> diabetes, hyperlipidemia, hypertension, other cardiovascular disease,
> and renal disease. Low dietary magnesium intake is correlated with
> insulin resistance in non-elderly African Americans without diabetes.

Correlations and associations does not mean causality.

> The American Diabetes Association (ADA) recognizes the increased risks
> associated with magnesium deficiency in patients with certain diseases
> or conditions (Table 1). In addition, the ADA recommends that magnesium
> levels be measured in such patients and repleted if deficient.
>
> Magnesium levels in patients with diabetes
> Many studies have shown that both mean plasma and intracellular free
> magnesium levels are lower in patients with diabetes than in the
> general population. This magnesium deficiency, which may take the form
> of a chronic latent magnesium deficit rather than clinical
> hypomagnesemia, may have clinical importance because the magnesium ion
> is a crucial cofactor for many enzymatic reactions involved in
> metabolic processes.
> http://www.mgwater.com/diabetes.shtml "

There has been no clinical evidence that magnesium deficiency
contributes to type-2 diabetes.

Indeed, for someone who is overeating, magnesium deficiency is less
likely than for someone who is eating the optimal amount. Those doing
the latter can simply take magnesium supplements in the form of tablets
or liquid as needed if there is a concern about magnesium deficiency
especially if there is constipation.

In the Holy Spirit,

Andrew <><
--
Andrew B. Chung, MD/PhD
http://EmoryCardiology.com

Andrew B. Chung, MD/PhD wrote:
> Convicted neighbor Kumar wrote:
> > Andrew, in the Holy Spirit, boldly wrote:
> > > Convicted neighbor Kumar wrote:
> > > > Andrew B. Chung, MD/PhD wrote:
> > > > > Convicted neighbor Kumar wrote:
> > > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > > Convicted neighbor Kumar wrote:
> > > > > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > > > > Convicted neighbor Kumar wrote:
> > > > > > > > > > Hello,
> > > > > > > > > > **Happy New Year**
> > > > > > > > > >
> > > > > > > > > > "Magnesium is an essential mineral to the human body. It is needed for
> > > > > > > > > > bone, protein, and fatty acid formation, making new cells, activating B
> > > > > > > > > > vitamins, relaxing muscles, clotting blood, and forming adenosine
> > > > > > > > > > triphosphate (ATP; the energy the body runs on). **The secretion and
> > > > > > > > > > action of insulin also require magnesium.
> > > > > > > > > >
> > > > > > > > > > Where is it found?
> > > > > > > > > > Nuts and grains are good sources of magnesium. Beans, dark green
> > > > > > > > > > vegetables, fish, and meat also contain significant amounts.
> > > > > > > > > >
> > > > > > > > > > Vitamin B6 increases the amount of magnesium that can enter cells. As a
> > > > > > > > > > result, these two nutrients are often taken together. Magnesium may
> > > > > > > > > > compete for absorption with other minerals, particularly calcium.
> > > > > > > > > > http://www.vitacost.com/Healthnotes/Supp/Magnesium.aspx "
> > > > > > > > > >
> > > > > > > > > > Many sites link Magnesium defficiencies with diabetes2.
> > > > > > > > > >
> > > > > > > > > > Can you guide how Magnesium is related to hyperglycemia, insulin
> > > > > > > > > > resistance..diabetes2?
> > > > > > > > > >
> > > > > > > > > > As such, whether Vit.B6, Sodium, Potassium and Calcium instabilities
> > > > > > > > > > can also be related?
> > > > > > > > >
> > > > > > > > > Nutritional deficiencies simply do not occur when there is overeating:
> > > > > > > >
> > > > > > > > "Eating Whole Grains, Nuts and Green Leafy Veggies May Help Ward Off
> > > > > > > > Type 2
> > > > > > > > -- Other Studies Show Weight-Loss Drug May Help Prevent Diabetes
> > > > > > > > Complications; ADA/AHA Statement Guiding Doctors on Use of TZDs
> > > > > > > >
> > > > > > > > (Alexandria, VA) - Two studies in the January issue of Diabetes Care
> > > > > > > > add weight to a growing body of evidence that a diet high in magnesium
> > > > > > > > may help prevent the development of type 2 diabetes, especially in
> > > > > > > > people who are overweight.
> > > > > > > >
> > > > > > > > Also in this month's journal: Two studies find additional benefits
> > > > > > > > to the weight-loss drug Orlistat, which researchers now believe may
> > > > > > > > lower free fatty acid levels, improve insulin sensitivity and lower the
> > > > > > > > chance of developing type 2 diabetes among people whose glucose
> > > > > > > > tolerance is already impaired; and a joint American Diabetes
> > > > > > > > Association/American Heart Association consensus statement provides
> > > > > > > > guidance to physicians in the use of glucose-lowering agents known as
> > > > > > > > thiazolidinediones (TZDs).
> > > > > > > > http://www.diabetes.org/for-media/di...e/12-23-03.jsp "
> > > > > > > >
> > > > > > > >
> > > > > > > > " Dietary magnesium lowers diabetes risk
> > > > > > > >
> > > > > > > >
> > > > > > > > Research suggests that nuts, grains, leafy green vegetables and other
> > > > > > > > foods high in magnesium may keep diabetes at bay. In recent studies,
> > > > > > > > people who consumed high magnesium diets were less likely to develop
> > > > > > > > type 2 diabetes.
> > > > > > > >
> > > > > > > > Until now, very few large studies have directly examined the long-term
> > > > > > > > effects of dietary magnesium on diabetes. Researchers at the Harvard
> > > > > > > > Medical School and School of Public Health in Boston provided some
> > > > > > > > direct evidence in their studies, that greater intake of dietary
> > > > > > > > magnesium may have a long-term protective effect on lowering diabetes
> > > > > > > > risk.
> > > > > > > >
> > > > > > > > In one of the studies, researchers evaluated the nutrition of about
> > > > > > > > 85,000 female nurses and more than 42,000 male health professionals
> > > > > > > > every 2 to 4 years. Women were followed for 18 years and the men for 12
> > > > > > > > years. In both men and women, those who consumed the most magnesium in
> > > > > > > > their diet were least likely to develop type 2 diabetes during the
> > > > > > > > study. This risk reduction was still present even after researchers
> > > > > > > > adjusted for factors that could have influenced the results, including
> > > > > > > > age, total caloric intake, family history of diabetes, physical
> > > > > > > > activity and alcohol consumption. Body mass index (BMI), did have some
> > > > > > > > effect, but the link between magnesium and a lower risk of diabetes was
> > > > > > > > still significant. Most of the participants got their magnesium from
> > > > > > > > food, and not vitamin supplements.
> > > > > > > >
> > > > > > > > The second study involved more than 39,000 women who had no history of
> > > > > > > > diabetes, heart disease or cancer. The women were followed for 6 years
> > > > > > > > to see if the amount of magnesium they consumed affected the odds of
> > > > > > > > developing diabetes. They found that women who consumed more magnesium
> > > > > > > > in their diet were less likely to develop diabetes. But the link
> > > > > > > > between magnesium and diabetes risk was seen only in women who had a
> > > > > > > > BMI of 25 or higher. Individuals with a BMI of 25 to 29.9 are
> > > > > > > > considered overweight, while those with a BMI of 30 or higher are
> > > > > > > > considered obese.
> > > > > > > >
> > > > > > > > The next step would be a randomised prospective clinical trial to test
> > > > > > > > the effect of consuming major food sources of magnesium, on the
> > > > > > > > development of type 2 diabetes in a high-risk population. In the
> > > > > > > > meantime, a diet rich in plant-based foods that are high in magnesium
> > > > > > > > may be beneficial for preventing diabetes.
> > > > > > > > http://www.doctorndtv.com/news/detailnews.asp?id=754 "
> > > > > > > >
> > > > > > > > Many sites indicate Mg defficiencies are common and its great link with
> > > > > > > > diabetes, obesity, HBP etc.
> > > > > > >
> > > > > > > There are folks who are selling magnesium to make money.
> > > > >
> > > > > > It is one of the important mineral.
> > > > >
> > > > > It is ubiquitously found in the soil and in the foods we eat.
> > > >
> > > > "Hypomagnesemia is an electrolyte disturbance in which there is an
> > > > abnormally low level of magnesium in the blood. Usually a serum level
> > > > less than 0.6 mmol/l is used as reference. **It must be noted that
> > > > hypomagnesemia is not equal to magnesium deficiency. Hypomagnesemia can
> > > > be present without magnesium deficiency and vice versa...
> > > > Magnesium deficiency is not uncommon in hospitalized patients. Elevated
> > > > levels of magnesium (hypermagnesemia), however, are nearly always
> > > > iatrogenic. 10-20% of all hospital patients, and 60-65% of patient in
> > > > the intensive care unit (ICU) have hypomagnesemia. **Hypomagnesiemia is
> > > > underdiagnosed, as testing for serum magnesium levels is not routine.
> > > > Hypomagnesemia results in increased mortality
> > > > http://en.wikipedia.org/wiki/Hypomagnesemia "
> > > >
> > > > It can be very important as;
> > > >
> > > > "Electrolyte disturbances
> > > > Hypokalemia: 42% of patients with hypokalemia also have hypomagnesemia,
> > > > not responding to potassium supplementation. Magnesium is needed for
> > > > the ATPase, Na-K-pump.
> > > > Hypocalcemia is present in 33% of patients in the intensive care unit,
> > > > not responding to calcium supplementation. This is because of decreased
> > > > function of the calcium pump, but also because of a decreased release
> > > > of calcium by inhibition of parathyroid hormone release.
> > > > http://en.wikipedia.org/wiki/Hypomagnesemia"
> > >
> > > Note that what you cite does not support a connection between
> > > hypomagnesemia and diabetes.
> >
> > Following quote can indicate it;
> >
> > "Magnesium needs in the American population
> > The Recommended Daily Allowance (RDA) for magnesium is 6 mg/kg/d. This
> > means 400 mg/d to 420 mg/d for adult men and 320 mg/d for adult women
> > (and even more for women who are pregnant or lactating). By these
> > standards, which have been promulgated by the National Academy of
> > Sciences and the Institute of Medicine after great deliberation,
> > research, and literature review, an estimated 50% to 85% of the
> > population of the United States is receiving an inadequate magnesium
> > intake.
> >
> > Levels of magnesium may be particularly low in certain populations,
> > such as African Americans. For example, the prevalence of
> > hypomagnesemia is 20% among urban African Americans in the city of
> > Buffalo, NY, and surrounding area. This exceeds the prevalence of
> > hypomagnesemia in the general population, and implies a risk for
> > diabetes, hyperlipidemia, hypertension, other cardiovascular disease,
> > and renal disease. Low dietary magnesium intake is correlated with
> > insulin resistance in non-elderly African Americans without diabetes.
>
> Correlations and associations does not mean causality.

Today, we may to understand many things, probably which remained normal
or not existed previously, in view of changed/changing environments and
lifestyles.


>
> > The American Diabetes Association (ADA) recognizes the increased risks
> > associated with magnesium deficiency in patients with certain diseases
> > or conditions (Table 1). In addition, the ADA recommends that magnesium
> > levels be measured in such patients and repleted if deficient.
> >
> > Magnesium levels in patients with diabetes
> > Many studies have shown that both mean plasma and intracellular free
> > magnesium levels are lower in patients with diabetes than in the
> > general population. This magnesium deficiency, which may take the form
> > of a chronic latent magnesium deficit rather than clinical
> > hypomagnesemia, may have clinical importance because the magnesium ion
> > is a crucial cofactor for many enzymatic reactions involved in
> > metabolic processes.
> > http://www.mgwater.com/diabetes.shtml "
>
> There has been no clinical evidence that magnesium deficiency
> contributes to type-2 diabetes.
>
> Indeed, for someone who is overeating, magnesium deficiency is less
> likely than for someone who is eating the optimal amount. Those doing
> the latter can simply take magnesium supplements in the form of tablets
> or liquid as needed if there is a concern about magnesium deficiency
> especially if there is constipation.

Particular attention towards it is being pursued nowdays but I see Mg
in different way--its relaxing vessels role. I am not sure, what is
more damaging on hypeglycemia/IR, relaxed vessels or contracted
vessels? Many abnormalities go but many also come.

Briefly, how can we differenciate African Americans(black) and American
Americans(white) esp. linked to blood flw variations, relaxed and
contracted vessels?
> In the Holy Spirit,
>
> Andrew <><
> --
> Andrew B. Chung, MD/PhD
> http://EmoryCardiology.com

Convicted neighbor Kumar wrote:
> Andrew, in the Holy Spirit, boldly wrote:
> > Convicted neighbor Kumar wrote:
> > > Andrew, in the Holy Spirit, boldly wrote:
> > > > Convicted neighbor Kumar wrote:
> > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > Convicted neighbor Kumar wrote:
> > > > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > > > Convicted neighbor Kumar wrote:
> > > > > > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > > > > > Convicted neighbor Kumar wrote:
> > > > > > > > > > > Hello,
> > > > > > > > > > > **Happy New Year**
> > > > > > > > > > >
> > > > > > > > > > > "Magnesium is an essential mineral to the human body. It is needed for
> > > > > > > > > > > bone, protein, and fatty acid formation, making new cells, activating B
> > > > > > > > > > > vitamins, relaxing muscles, clotting blood, and forming adenosine
> > > > > > > > > > > triphosphate (ATP; the energy the body runs on). **The secretion and
> > > > > > > > > > > action of insulin also require magnesium.
> > > > > > > > > > >
> > > > > > > > > > > Where is it found?
> > > > > > > > > > > Nuts and grains are good sources of magnesium. Beans, dark green
> > > > > > > > > > > vegetables, fish, and meat also contain significant amounts.
> > > > > > > > > > >
> > > > > > > > > > > Vitamin B6 increases the amount of magnesium that can enter cells. As a
> > > > > > > > > > > result, these two nutrients are often taken together. Magnesium may
> > > > > > > > > > > compete for absorption with other minerals, particularly calcium.
> > > > > > > > > > > http://www.vitacost.com/Healthnotes/Supp/Magnesium.aspx "
> > > > > > > > > > >
> > > > > > > > > > > Many sites link Magnesium defficiencies with diabetes2.
> > > > > > > > > > >
> > > > > > > > > > > Can you guide how Magnesium is related to hyperglycemia, insulin
> > > > > > > > > > > resistance..diabetes2?
> > > > > > > > > > >
> > > > > > > > > > > As such, whether Vit.B6, Sodium, Potassium and Calcium instabilities
> > > > > > > > > > > can also be related?
> > > > > > > > > >
> > > > > > > > > > Nutritional deficiencies simply do not occur when there is overeating:
> > > > > > > > >
> > > > > > > > > "Eating Whole Grains, Nuts and Green Leafy Veggies May Help Ward Off
> > > > > > > > > Type 2
> > > > > > > > > -- Other Studies Show Weight-Loss Drug May Help Prevent Diabetes
> > > > > > > > > Complications; ADA/AHA Statement Guiding Doctors on Use of TZDs
> > > > > > > > >
> > > > > > > > > (Alexandria, VA) - Two studies in the January issue of Diabetes Care
> > > > > > > > > add weight to a growing body of evidence that a diet high in magnesium
> > > > > > > > > may help prevent the development of type 2 diabetes, especially in
> > > > > > > > > people who are overweight.
> > > > > > > > >
> > > > > > > > > Also in this month's journal: Two studies find additional benefits
> > > > > > > > > to the weight-loss drug Orlistat, which researchers now believe may
> > > > > > > > > lower free fatty acid levels, improve insulin sensitivity and lower the
> > > > > > > > > chance of developing type 2 diabetes among people whose glucose
> > > > > > > > > tolerance is already impaired; and a joint American Diabetes
> > > > > > > > > Association/American Heart Association consensus statement provides
> > > > > > > > > guidance to physicians in the use of glucose-lowering agents known as
> > > > > > > > > thiazolidinediones (TZDs).
> > > > > > > > > http://www.diabetes.org/for-media/di...e/12-23-03.jsp "
> > > > > > > > >
> > > > > > > > >
> > > > > > > > > " Dietary magnesium lowers diabetes risk
> > > > > > > > >
> > > > > > > > >
> > > > > > > > > Research suggests that nuts, grains, leafy green vegetables and other
> > > > > > > > > foods high in magnesium may keep diabetes at bay. In recent studies,
> > > > > > > > > people who consumed high magnesium diets were less likely to develop
> > > > > > > > > type 2 diabetes.
> > > > > > > > >
> > > > > > > > > Until now, very few large studies have directly examined the long-term
> > > > > > > > > effects of dietary magnesium on diabetes. Researchers at the Harvard
> > > > > > > > > Medical School and School of Public Health in Boston provided some
> > > > > > > > > direct evidence in their studies, that greater intake of dietary
> > > > > > > > > magnesium may have a long-term protective effect on lowering diabetes
> > > > > > > > > risk.
> > > > > > > > >
> > > > > > > > > In one of the studies, researchers evaluated the nutrition of about
> > > > > > > > > 85,000 female nurses and more than 42,000 male health professionals
> > > > > > > > > every 2 to 4 years. Women were followed for 18 years and the men for 12
> > > > > > > > > years. In both men and women, those who consumed the most magnesium in
> > > > > > > > > their diet were least likely to develop type 2 diabetes during the
> > > > > > > > > study. This risk reduction was still present even after researchers
> > > > > > > > > adjusted for factors that could have influenced the results, including
> > > > > > > > > age, total caloric intake, family history of diabetes, physical
> > > > > > > > > activity and alcohol consumption. Body mass index (BMI), did have some
> > > > > > > > > effect, but the link between magnesium and a lower risk of diabetes was
> > > > > > > > > still significant. Most of the participants got their magnesium from
> > > > > > > > > food, and not vitamin supplements.
> > > > > > > > >
> > > > > > > > > The second study involved more than 39,000 women who had no history of
> > > > > > > > > diabetes, heart disease or cancer. The women were followed for 6 years
> > > > > > > > > to see if the amount of magnesium they consumed affected the odds of
> > > > > > > > > developing diabetes. They found that women who consumed more magnesium
> > > > > > > > > in their diet were less likely to develop diabetes. But the link
> > > > > > > > > between magnesium and diabetes risk was seen only in women who had a
> > > > > > > > > BMI of 25 or higher. Individuals with a BMI of 25 to 29.9 are
> > > > > > > > > considered overweight, while those with a BMI of 30 or higher are
> > > > > > > > > considered obese.
> > > > > > > > >
> > > > > > > > > The next step would be a randomised prospective clinical trial to test
> > > > > > > > > the effect of consuming major food sources of magnesium, on the
> > > > > > > > > development of type 2 diabetes in a high-risk population. In the
> > > > > > > > > meantime, a diet rich in plant-based foods that are high in magnesium
> > > > > > > > > may be beneficial for preventing diabetes.
> > > > > > > > > http://www.doctorndtv.com/news/detailnews.asp?id=754 "
> > > > > > > > >
> > > > > > > > > Many sites indicate Mg defficiencies are common and its great link with
> > > > > > > > > diabetes, obesity, HBP etc.
> > > > > > > >
> > > > > > > > There are folks who are selling magnesium to make money.
> > > > > >
> > > > > > > It is one of the important mineral.
> > > > > >
> > > > > > It is ubiquitously found in the soil and in the foods we eat.
> > > > >
> > > > > "Hypomagnesemia is an electrolyte disturbance in which there is an
> > > > > abnormally low level of magnesium in the blood. Usually a serum level
> > > > > less than 0.6 mmol/l is used as reference. **It must be noted that
> > > > > hypomagnesemia is not equal to magnesium deficiency. Hypomagnesemia can
> > > > > be present without magnesium deficiency and vice versa...
> > > > > Magnesium deficiency is not uncommon in hospitalized patients. Elevated
> > > > > levels of magnesium (hypermagnesemia), however, are nearly always
> > > > > iatrogenic. 10-20% of all hospital patients, and 60-65% of patient in
> > > > > the intensive care unit (ICU) have hypomagnesemia. **Hypomagnesiemia is
> > > > > underdiagnosed, as testing for serum magnesium levels is not routine.
> > > > > Hypomagnesemia results in increased mortality
> > > > > http://en.wikipedia.org/wiki/Hypomagnesemia "
> > > > >
> > > > > It can be very important as;
> > > > >
> > > > > "Electrolyte disturbances
> > > > > Hypokalemia: 42% of patients with hypokalemia also have hypomagnesemia,
> > > > > not responding to potassium supplementation. Magnesium is needed for
> > > > > the ATPase, Na-K-pump.
> > > > > Hypocalcemia is present in 33% of patients in the intensive care unit,
> > > > > not responding to calcium supplementation. This is because of decreased
> > > > > function of the calcium pump, but also because of a decreased release
> > > > > of calcium by inhibition of parathyroid hormone release.
> > > > > http://en.wikipedia.org/wiki/Hypomagnesemia"
> > > >
> > > > Note that what you cite does not support a connection between
> > > > hypomagnesemia and diabetes.
> > >
> > > Following quote can indicate it;
> > >
> > > "Magnesium needs in the American population
> > > The Recommended Daily Allowance (RDA) for magnesium is 6 mg/kg/d. This
> > > means 400 mg/d to 420 mg/d for adult men and 320 mg/d for adult women
> > > (and even more for women who are pregnant or lactating). By these
> > > standards, which have been promulgated by the National Academy of
> > > Sciences and the Institute of Medicine after great deliberation,
> > > research, and literature review, an estimated 50% to 85% of the
> > > population of the United States is receiving an inadequate magnesium
> > > intake.
> > >
> > > Levels of magnesium may be particularly low in certain populations,
> > > such as African Americans. For example, the prevalence of
> > > hypomagnesemia is 20% among urban African Americans in the city of
> > > Buffalo, NY, and surrounding area. This exceeds the prevalence of
> > > hypomagnesemia in the general population, and implies a risk for
> > > diabetes, hyperlipidemia, hypertension, other cardiovascular disease,
> > > and renal disease. Low dietary magnesium intake is correlated with
> > > insulin resistance in non-elderly African Americans without diabetes.
> >
> > Correlations and associations does not mean causality.
>
> Today, we may to understand many things, probably which remained normal
> or not existed previously, in view of changed/changing environments and
> lifestyles.

Increased dietary intake of magnesium has not had any observed clinical
impact on type-2 diabetes.

> > > The American Diabetes Association (ADA) recognizes the increased risks
> > > associated with magnesium deficiency in patients with certain diseases
> > > or conditions (Table 1). In addition, the ADA recommends that magnesium
> > > levels be measured in such patients and repleted if deficient.
> > >
> > > Magnesium levels in patients with diabetes
> > > Many studies have shown that both mean plasma and intracellular free
> > > magnesium levels are lower in patients with diabetes than in the
> > > general population. This magnesium deficiency, which may take the form
> > > of a chronic latent magnesium deficit rather than clinical
> > > hypomagnesemia, may have clinical importance because the magnesium ion
> > > is a crucial cofactor for many enzymatic reactions involved in
> > > metabolic processes.
> > > http://www.mgwater.com/diabetes.shtml "
> >
> > There has been no clinical evidence that magnesium deficiency
> > contributes to type-2 diabetes.
> >
> > Indeed, for someone who is overeating, magnesium deficiency is less
> > likely than for someone who is eating the optimal amount. Those doing
> > the latter can simply take magnesium supplements in the form of tablets
> > or liquid as needed if there is a concern about magnesium deficiency
> > especially if there is constipation.
>
> Particular attention towards it is being pursued nowdays but I see Mg
> in different way--its relaxing vessels role. I am not sure, what is
> more damaging on hypeglycemia/IR, relaxed vessels or contracted
> vessels? Many abnormalities go but many also come.

Magnesium is not known to impact the function of the endothelium.

> Briefly, how can we differenciate African Americans(black) and American
> Americans(white) esp. linked to blood flw variations, relaxed and
> contracted vessels?

No clinical difference between Caucasian Americans and African
Americans in the function of their endothelium.

In the Holy Spirit,

Andrew <><
--
Andrew B. Chung, MD/PhD
http://EmoryCardiology.com

Andrew B. Chung, MD/PhD wrote:
> > > > > > "Electrolyte disturbances
> > > > > > Hypokalemia: 42% of patients with hypokalemia also have hypomagnesemia,
> > > > > > not responding to potassium supplementation. Magnesium is needed for
> > > > > > the ATPase, Na-K-pump.
> > > > > > Hypocalcemia is present in 33% of patients in the intensive care unit,
> > > > > > not responding to calcium supplementation. This is because of decreased
> > > > > > function of the calcium pump, but also because of a decreased release
> > > > > > of calcium by inhibition of parathyroid hormone release.
> > > > > > http://en.wikipedia.org/wiki/Hypomagnesemia"
> > > > >
> > > > > Note that what you cite does not support a connection between
> > > > > hypomagnesemia and diabetes.
> > > >
> > > > Following quote can indicate it;
> > > >
> > > > "Magnesium needs in the American population
> > > > The Recommended Daily Allowance (RDA) for magnesium is 6 mg/kg/d. This
> > > > means 400 mg/d to 420 mg/d for adult men and 320 mg/d for adult women
> > > > (and even more for women who are pregnant or lactating). By these
> > > > standards, which have been promulgated by the National Academy of
> > > > Sciences and the Institute of Medicine after great deliberation,
> > > > research, and literature review, an estimated 50% to 85% of the
> > > > population of the United States is receiving an inadequate magnesium
> > > > intake.
> > > >
> > > > Levels of magnesium may be particularly low in certain populations,
> > > > such as African Americans. For example, the prevalence of
> > > > hypomagnesemia is 20% among urban African Americans in the city of
> > > > Buffalo, NY, and surrounding area. This exceeds the prevalence of
> > > > hypomagnesemia in the general population, and implies a risk for
> > > > diabetes, hyperlipidemia, hypertension, other cardiovascular disease,
> > > > and renal disease. Low dietary magnesium intake is correlated with
> > > > insulin resistance in non-elderly African Americans without diabetes.
> > >
> > > Correlations and associations does not mean causality.
> >
> > Today, we may to understand many things, probably which remained normal
> > or not existed previously, in view of changed/changing environments and
> > lifestyles.
>
> Increased dietary intake of magnesium has not had any observed clinical
> impact on type-2 diabetes.
>
> > > > The American Diabetes Association (ADA) recognizes the increased risks
> > > > associated with magnesium deficiency in patients with certain diseases
> > > > or conditions (Table 1). In addition, the ADA recommends that magnesium
> > > > levels be measured in such patients and repleted if deficient.
> > > >
> > > > Magnesium levels in patients with diabetes
> > > > Many studies have shown that both mean plasma and intracellular free
> > > > magnesium levels are lower in patients with diabetes than in the
> > > > general population. This magnesium deficiency, which may take the form
> > > > of a chronic latent magnesium deficit rather than clinical
> > > > hypomagnesemia, may have clinical importance because the magnesium ion
> > > > is a crucial cofactor for many enzymatic reactions involved in
> > > > metabolic processes.
> > > > http://www.mgwater.com/diabetes.shtml "
> > >
> > > There has been no clinical evidence that magnesium deficiency
> > > contributes to type-2 diabetes.
> > >
> > > Indeed, for someone who is overeating, magnesium deficiency is less
> > > likely than for someone who is eating the optimal amount. Those doing
> > > the latter can simply take magnesium supplements in the form of tablets
> > > or liquid as needed if there is a concern about magnesium deficiency
> > > especially if there is constipation.
> >
> > Particular attention towards it is being pursued nowdays but I see Mg
> > in different way--its relaxing vessels role. I am not sure, what is
> > more damaging on hypeglycemia/IR, relaxed vessels or contracted
> > vessels? Many abnormalities go but many also come.
>
> Magnesium is not known to impact the function of the endothelium.

But I think, its effect is indicated on relaxing muscula tone of blood
vessels?
> > Briefly, how can we differenciate African Americans(black) and American
> > Americans(white) esp. linked to blood flow variations, relaxed and
> > contracted vessels?
>
> No clinical difference between Caucasian Americans and African
> Americans in the function of their endothelium.
Probably, African Americans are predisposed to get relaxed muscles
conditions and more blood flow, may be effected either by heat or their
complexion? Are they differenciated in blood pressure, early and
enhanced growth, early aging etc.,iron overload type problems?
> In the Holy Spirit,
>
> Andrew <><
> --
> Andrew B. Chung, MD/PhD
> http://EmoryCardiology.com

In article <1168351270.086644.228430@42g2000cwt.googlegroups. com>, "Andrew
B. Chung, MD/PhD" <achung@emorycardiology.com> wrote:

Convicted neighbor Kumar wrote:
> Andrew, in the Holy Spirit, boldly wrote:
> > Convicted neighbor Kumar wrote:
> > > Andrew, in the Holy Spirit, boldly wrote:
> > > > Convicted neighbor Kumar wrote:
> > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > Convicted neighbor Kumar wrote:
> > > > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > > > Convicted neighbor Kumar wrote:
> > > > > > > > > Andrew B. Chung, MD/PhD wrote:
> > > > > > > > > > Convicted neighbor Kumar wrote:
> > > > > > > > > > > Hello,
> > > > > > > > > > > **Happy New Year**
> > > > > > > > > > >
> > > > > > > > > > > "Magnesium is an essential mineral to the human
body. It is needed for
> > > > > > > > > > > bone, protein, and fatty acid formation, making new
cells, activating B
> > > > > > > > > > > vitamins, relaxing muscles, clotting blood, and
forming adenosine
> > > > > > > > > > > triphosphate (ATP; the energy the body runs on).
**The secretion and
> > > > > > > > > > > action of insulin also require magnesium.
> > > > > > > > > > >
> > > > > > > > > > > Where is it found?
> > > > > > > > > > > Nuts and grains are good sources of magnesium.
Beans, dark green
> > > > > > > > > > > vegetables, fish, and meat also contain significant
amounts.
> > > > > > > > > > >
> > > > > > > > > > > Vitamin B6 increases the amount of magnesium that
can enter cells. As a
> > > > > > > > > > > result, these two nutrients are often taken
together. Magnesium may
> > > > > > > > > > > compete for absorption with other minerals,
particularly calcium.
> > > > > > > > > > > http://www.vitacost.com/Healthnotes/Supp/Magnesium.aspx "
> > > > > > > > > > >
> > > > > > > > > > > Many sites link Magnesium defficiencies with diabetes2.
> > > > > > > > > > >
> > > > > > > > > > > Can you guide how Magnesium is related to
hyperglycemia, insulin
> > > > > > > > > > > resistance..diabetes2?
> > > > > > > > > > >
> > > > > > > > > > > As such, whether Vit.B6, Sodium, Potassium and
Calcium instabilities
> > > > > > > > > > > can also be related?
> > > > > > > > > >
> > > > > > > > > > Nutritional deficiencies simply do not occur when
there is overeating:
> > > > > > > > >
> > > > > > > > > "Eating Whole Grains, Nuts and Green Leafy Veggies May
Help Ward Off
> > > > > > > > > Type 2
> > > > > > > > > -- Other Studies Show Weight-Loss Drug May Help Prevent
Diabetes
> > > > > > > > > Complications; ADA/AHA Statement Guiding Doctors on Use
of TZDs
> > > > > > > > >
> > > > > > > > > (Alexandria, VA) - Two studies in the January issue of
Diabetes Care
> > > > > > > > > add weight to a growing body of evidence that a diet
high in magnesium
> > > > > > > > > may help prevent the development of type 2 diabetes,
especially in
> > > > > > > > > people who are overweight.
> > > > > > > > >
> > > > > > > > > Also in this month's journal: Two studies find
additional benefits
> > > > > > > > > to the weight-loss drug Orlistat, which researchers now
believe may
> > > > > > > > > lower free fatty acid levels, improve insulin
sensitivity and lower the
> > > > > > > > > chance of developing type 2 diabetes among people whose
glucose
> > > > > > > > > tolerance is already impaired; and a joint American Diabetes
> > > > > > > > > Association/American Heart Association consensus
statement provides
> > > > > > > > > guidance to physicians in the use of glucose-lowering
agents known as
> > > > > > > > > thiazolidinediones (TZDs).
> > > > > > > > >
http://www.diabetes.org/for-media/di...e/12-23-03.jsp "
> > > > > > > > >
> > > > > > > > >
> > > > > > > > > " Dietary magnesium lowers diabetes risk
> > > > > > > > >
> > > > > > > > >
> > > > > > > > > Research suggests that nuts, grains, leafy green
vegetables and other
> > > > > > > > > foods high in magnesium may keep diabetes at bay. In
recent studies,
> > > > > > > > > people who consumed high magnesium diets were less
likely to develop
> > > > > > > > > type 2 diabetes.
> > > > > > > > >
> > > > > > > > > Until now, very few large studies have directly
examined the long-term
> > > > > > > > > effects of dietary magnesium on diabetes. Researchers
at the Harvard
> > > > > > > > > Medical School and School of Public Health in Boston
provided some
> > > > > > > > > direct evidence in their studies, that greater intake
of dietary
> > > > > > > > > magnesium may have a long-term protective effect on
lowering diabetes
> > > > > > > > > risk.
> > > > > > > > >
> > > > > > > > > In one of the studies, researchers evaluated the
nutrition of about
> > > > > > > > > 85,000 female nurses and more than 42,000 male health
professionals
> > > > > > > > > every 2 to 4 years. Women were followed for 18 years
and the men for 12
> > > > > > > > > years. In both men and women, those who consumed the
most magnesium in
> > > > > > > > > their diet were least likely to develop type 2 diabetes
during the
> > > > > > > > > study. This risk reduction was still present even after
researchers
> > > > > > > > > adjusted for factors that could have influenced the
results, including
> > > > > > > > > age, total caloric intake, family history of diabetes,
physical
> > > > > > > > > activity and alcohol consumption. Body mass index
(BMI), did have some
> > > > > > > > > effect, but the link between magnesium and a lower risk
of diabetes was
> > > > > > > > > still significant. Most of the participants got their
magnesium from
> > > > > > > > > food, and not vitamin supplements.
> > > > > > > > >
> > > > > > > > > The second study involved more than 39,000 women who
had no history of
> > > > > > > > > diabetes, heart disease or cancer. The women were
followed for 6 years
> > > > > > > > > to see if the amount of magnesium they consumed
affected the odds of
> > > > > > > > > developing diabetes. They found that women who consumed
more magnesium
> > > > > > > > > in their diet were less likely to develop diabetes. But
the link
> > > > > > > > > between magnesium and diabetes risk was seen only in
women who had a
> > > > > > > > > BMI of 25 or higher. Individuals with a BMI of 25 to 29.9 are
> > > > > > > > > considered overweight, while those with a BMI of 30 or
higher are
> > > > > > > > > considered obese.
> > > > > > > > >
> > > > > > > > > The next step would be a randomised prospective
clinical trial to test
> > > > > > > > > the effect of consuming major food sources of
magnesium, on the
> > > > > > > > > development of type 2 diabetes in a high-risk
population. In the
> > > > > > > > > meantime, a diet rich in plant-based foods that are
high in magnesium
> > > > > > > > > may be beneficial for preventing diabetes.
> > > > > > > > > http://www.doctorndtv.com/news/detailnews.asp?id=754 "
> > > > > > > > >
> > > > > > > > > Many sites indicate Mg defficiencies are common and its
great link with
> > > > > > > > > diabetes, obesity, HBP etc.
> > > > > > > >
> > > > > > > > There are folks who are selling magnesium to make money.
> > > > > >
> > > > > > > It is one of the important mineral.
> > > > > >
> > > > > > It is ubiquitously found in the soil and in the foods we eat.
> > > > >
> > > > > "Hypomagnesemia is an electrolyte disturbance in which there is an
> > > > > abnormally low level of magnesium in the blood. Usually a serum level
> > > > > less than 0.6 mmol/l is used as reference. **It must be noted that
> > > > > hypomagnesemia is not equal to magnesium deficiency.
Hypomagnesemia can
> > > > > be present without magnesium deficiency and vice versa...
> > > > > Magnesium deficiency is not uncommon in hospitalized patients.
Elevated
> > > > > levels of magnesium (hypermagnesemia), however, are nearly always
> > > > > iatrogenic. 10-20% of all hospital patients, and 60-65% of patient in
> > > > > the intensive care unit (ICU) have hypomagnesemia.
**Hypomagnesiemia is
> > > > > underdiagnosed, as testing for serum magnesium levels is not routine.
> > > > > Hypomagnesemia results in increased mortality
> > > > > http://en.wikipedia.org/wiki/Hypomagnesemia "
> > > > >
> > > > > It can be very important as;
> > > > >
> > > > > "Electrolyte disturbances
> > > > > Hypokalemia: 42% of patients with hypokalemia also have
hypomagnesemia,
> > > > > not responding to potassium supplementation. Magnesium is needed for
> > > > > the ATPase, Na-K-pump.
> > > > > Hypocalcemia is present in 33% of patients in the intensive
care unit,
> > > > > not responding to calcium supplementation. This is because of
decreased
> > > > > function of the calcium pump, but also because of a decreased release
> > > > > of calcium by inhibition of parathyroid hormone release.
> > > > > http://en.wikipedia.org/wiki/Hypomagnesemia"
> > > >
> > > > Note that what you cite does not support a connection between
> > > > hypomagnesemia and diabetes.
> > >
> > > Following quote can indicate it;
> > >
> > > "Magnesium needs in the American population
> > > The Recommended Daily Allowance (RDA) for magnesium is 6 mg/kg/d. This
> > > means 400 mg/d to 420 mg/d for adult men and 320 mg/d for adult women
> > > (and even more for women who are pregnant or lactating). By these
> > > standards, which have been promulgated by the National Academy of
> > > Sciences and the Institute of Medicine after great deliberation,
> > > research, and literature review, an estimated 50% to 85% of the
> > > population of the United States is receiving an inadequate magnesium
> > > intake.
> > >
> > > Levels of magnesium may be particularly low in certain populations,
> > > such as African Americans. For example, the prevalence of
> > > hypomagnesemia is 20% among urban African Americans in the city of
> > > Buffalo, NY, and surrounding area. This exceeds the prevalence of
> > > hypomagnesemia in the general population, and implies a risk for
> > > diabetes, hyperlipidemia, hypertension, other cardiovascular disease,
> > > and renal disease. Low dietary magnesium intake is correlated with
> > > insulin resistance in non-elderly African Americans without diabetes.
> >
> > Correlations and associations does not mean causality.
>
> Today, we may to understand many things, probably which remained normal
> or not existed previously, in view of changed/changing environments and
> lifestyles.

Increased dietary intake of magnesium has not had any observed clinical
impact on type-2 diabetes.

> > > The American Diabetes Association (ADA) recognizes the increased risks
> > > associated with magnesium deficiency in patients with certain diseases
> > > or conditions (Table 1). In addition, the ADA recommends that magnesium
> > > levels be measured in such patients and repleted if deficient.
> > >
> > > Magnesium levels in patients with diabetes
> > > Many studies have shown that both mean plasma and intracellular free
> > > magnesium levels are lower in patients with diabetes than in the
> > > general population. This magnesium deficiency, which may take the form
> > > of a chronic latent magnesium deficit rather than clinical
> > > hypomagnesemia, may have clinical importance because the magnesium ion
> > > is a crucial cofactor for many enzymatic reactions involved in
> > > metabolic processes.
> > > http://www.mgwater.com/diabetes.shtml "
> >
> > There has been no clinical evidence that magnesium deficiency
> > contributes to type-2 diabetes.
> >
> > Indeed, for someone who is overeating, magnesium deficiency is less
> > likely than for someone who is eating the optimal amount. Those doing
> > the latter can simply take magnesium supplements in the form of tablets
> > or liquid as needed if there is a concern about magnesium deficiency
> > especially if there is constipation.
>
> Particular attention towards it is being pursued nowdays but I see Mg
> in different way--its relaxing vessels role. I am not sure, what is
> more damaging on hypeglycemia/IR, relaxed vessels or contracted
> vessels? Many abnormalities go but many also come.

Magnesium is not known to impact the function of the endothelium.

> Briefly, how can we differenciate African Americans(black) and American
> Americans(white) esp. linked to blood flw variations, relaxed and
> contracted vessels?

No clinical difference between Caucasian Americans and African
Americans in the function of their endothelium.

In the Holy Spirit,

Andrew <><
--
Andrew B. Chung, MD/PhD
http://EmoryCardiology.com

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Dr. Chung,
Harvard researchers (in a study) found out that the more magnesium the
test subjects consumed, the less their risk of developing Type 2 diabetes.

"These findings support a protective role of higher intake of magnesium in
reducing the risk of developing type-2 diabetes, especially in overweight
women."

If you have that issue, read the article on page 59-65 and the other
article on page 134-140

I realize that other studies might have had a different result.

Have a Happy New Year,
Jason
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Source:
January 2004 edition of the journal of "Diabetes Care".