Re: More bad news about diabetes drugs

friend bigvince wrote:
>
> Diabetes Drugs Increase Risk of Heart Failure
> WINSTON-SALEM, NC -- July 27, 2007 -- A class of drugs commonly used
> to treat type 2 diabetes may double the risk of heart failure,
> according to a new analysis by researchers at Wake Forest University
> School of Medicine and colleagues.
>
> "Based on a review of research studies and case reports involving
> more than 78,000 patients, the authors concluded that the risk of
> heart failure may be up to 100 percent higher (depending on the type
> of study) in patients taking thiazolinediones (which includes Avandia®
> and Actos®). These drugs are known to enhance insulin sensitivity.
>
> The authors estimated that one additional patient with type 2 diabetes
> would develop heart failure for every 50 patients taking the drugs
> over a 26-month period.
>
> The results were published online in May 2007 by Diabetes Care and
> will appear in the August print issue.
>
> "These drugs are currently used by more than 3 million diabetic
> patients in the U.S. alone, suggesting that several thousand could be
> harmed," said Sonal Singh, MD, lead author and an assistant professor
> in internal medicine at Wake Forest.
>
> Earlier this year, one of the drugs in this class (Avandia®) was
> linked to an increased risk of heart attack and death from
> cardiovascular causes."
>
> The authors also noted
>
> " The product label for both drugs warns against their use in
> patients with more severe cases of heart failure. The label also
> cautions about the increased risk of heart failure if used in
> combination with insulin. However, the current analysis found that the
> risk wasn't confined just to patients on insulin, and it occurred even
> among patients without any risk factors for heart failure. "Our
> findings support current efforts by the FDA to add a black box warning
> to the labeling for those agents," said co-investigator Curt Furberg,
> MD, PhD, from Wake Forest.
>
> "The occurrence of heart failure several months after initiation of
> treatment suggests a long-term effect of the drugs, which may not be
> avoided by beginning with low doses," said Singh."
>
> From DG news
> http://www.docguide.com/news/content...BB&c=&count=10

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Prayerfully in Jesus' awesome love,

Andrew <><
--
Andrew B. Chung, MD/PhD
Cardiologist