Reducing insulin signalling in the brain can prolong lifespan

Reducing insulin in the brain can prolong lifespan:

http://www.virtualmedicalcentre.com/...sp?artid=10362

Therefore, it remains much smarter to eat less, down to the right
amount:

http://HeartMDPhD.com/BeSmart

A simple parable that hopefully will promote understanding:

http://HeartMDPhD.com/Parable

Be hungry... be healthy... be hungrier... be euglycemic:

http://TheWellnessFoundation.com/BeHealthier

Prayerfully in the infinite power and might of the Holy Spirit,

Andrew <><
--
Andrew B. Chung, MD/PhD
Lawful steward of http://EmoryCardiology.com
A latter-day disciple of the KING of kings and LORD of lords.
http://HeartMDPhD.com/HolySpirit/DiscipleNow

Robert Miles wrote:
> Reducing insulin in the brain can prolong lifespan:
>
> http://www.virtualmedicalcentre.com/...sp?artid=10362

In alt.support.diabetes Robert Miles <robertmiles@bellsouthnospam.net> wrote:
> Reducing insulin in the brain can prolong lifespan:

> http://www.virtualmedicalcentre.com/...sp?artid=10362

I wonder if that applies to animals and would be enough to explain the
extra longevity that comes from reducing food intake in animal
studies?

--
Chris Malcolm cam@infirmatics.ed.ac.uk DoD #205
IPAB, Informatics, JCMB, King's Buildings, Edinburgh, EH9 3JZ, UK
[http://www.dai.ed.ac.uk/homes/cam/]

It is smarter to apply animal studies to humans rather than the other
way around.

It also remains smarter to eat less, down to the right amount based on
the data from animal studies:

http://HeartMDPhD.com/BeSmart

A simple animal parable given in hopes of promoting understanding:

http://HeartMDPhD.com/Parable

Be hungry... be healthy... be hungrier... be euglycemic:

http://TheWellnessFoundation.com/BeHealthier

Prayerfully in the infinite power and might of the Holy Spirit,

Andrew <><
--
Andrew B. Chung, MD/PhD
Lawful steward of http://EmoryCardiology.com
A latter-day disciple of the KING of kings and LORD of lords.
http://HeartMDPhD.com/HolySpirit/DiscipleNow


convicted friend Chris Malcolm wrote:
> convicted neighbor Robert Miles <robertmiles@bellsouthnospam.net> wrote:
>
> > Reducing insulin in the brain can prolong lifespan:
>
> > http://www.virtualmedicalcentre.com/...sp?artid=10362
>
> I wonder if that applies to animals and would be enough to explain the
> extra longevity that comes from reducing food intake in animal
> studies?
>
> --
> Chris Malcolm cam@infirmatics.ed.ac.uk DoD #205
> IPAB, Informatics, JCMB, King's Buildings, Edinburgh, EH9 3JZ, UK
> [http://www.dai.ed.ac.uk/homes/cam/]

Chris Malcolm wrote:

> In alt.support.diabetes Robert Miles <robertmiles@bellsouthnospam.net> wrote:
>
>>Reducing insulin in the brain can prolong lifespan:
>
>
>>http://www.virtualmedicalcentre.com/...sp?artid=10362
>
>
> I wonder if that applies to animals and would be enough to explain the
> extra longevity that comes from reducing food intake in animal
> studies?
>

More than likely the extended life is due to a combined effect of
calorie and carbohydrate restriction. The brain and the rest of the
body would be impacted. Resveratrol has some of the same effects as
calorie restriction.

"First U.S. Patent Issued For New Class of Drugs To Treat Diabetes

Sirtris Pharmaceuticals, Inc., has been issued a patent for a new class
of drugs called SIRT1 Activators (resveratrol), which lower glucose and
improve insulin sensitivity In preclinical models of type 2 diabetes.

Sirtris Pharmaceuticals, Inc., a biopharmaceutical company focused on
discovering and developing small molecule drugs to treat diseases of
aging such as Type 2 Diabetes, last week that the United States Patent
Office issued to Sirtris the first patent covering a broad class of
compounds that activate the enzyme SIRT1. Several Sirtris compounds - or
new chemical entities (NCEs) - from this class lower glucose and improve
insulin sensitivity in preclinical models of Type 2 Diabetes. The patent
covers the first NCE that Sirtris plans to take into a human clinical
safety trial in the first half of 2008.
http://www.diabetesincontrol.com/results_print.php?storyarticle=5641"

Notice that most of the diseases in the newsrelease below are of the brain.

Sirtris Pharmaceuticals Scientific Advisor Shows SIRT1 Activation
Improves Huntington's Disease In Preclinical Model -
http://tinyurl.com/52efp3

Sirtris Pharmaceuticals Initiates Phase Ib Clinical Trial of SRT501 -
http://tinyurl.com/3ekjog

The side spanners can list some of the other Sirtris small molecules
being developed,i.e., SRTx where x is a variable number.

Frank