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When Metformin Isn't Enough
  1. #1
    [email protected] Guest

    Default When Metformin Isn't Enough

    http://www.diabetes.org/diabetes-res...snt-enough.jsp

    (for Chris Malcolm)

    http://care.diabetesjournals.org/cgi...stract/32/1/84

    (excerpt)

    What did the researchers find?
    Adding liraglutide to metformin provided better diabetes control than
    metformin alone. The liraglutide-metformin combination controlled
    blood glucose as well as and caused less weight gain and hypoglycemia
    than a combination of glimepiride and metformin. Liraglutide caused
    more nausea than glimepiride, but the nausea declined over time.


  2. #2
    ray Guest

    Default Re: When Metformin Isn't Enough

    On Sun, 01 Mar 2009 11:47:27 -0800, kurtwheeling1965 wrote:

    > http://www.diabetes.org/diabetes-res...etformin-isnt-

    enough.jsp
    >
    > (for Chris Malcolm)
    >
    > http://care.diabetesjournals.org/cgi...stract/32/1/84
    >
    > (excerpt)
    >
    > What did the researchers find?
    > Adding liraglutide to metformin provided better diabetes control than
    > metformin alone. The liraglutide-metformin combination controlled blood
    > glucose as well as and caused less weight gain and hypoglycemia than a
    > combination of glimepiride and metformin. Liraglutide caused more nausea
    > than glimepiride, but the nausea declined over time.


    I find that for me, metformin alone is not enough. Neither is exercise
    alone or diet (low carb) alone. Matter of fact, no two of them seem to
    suffice - but ALL THREE TOGETHER work very well.

  3. #3
    Loretta Eisenberg Guest

    Default Re: When Metformin Isn't Enough

    Kurt, for me adding byetta to the mix did the trick for me.

    talk about nausea, byetta caused it for a long time , hence I couldnt
    eat, then it stopped making me sick and my appetitite returned


  4. #4
    [email protected] Guest

    Default Re: When Metformin Isn't Enough

    On Mar 1, 2:50�pm, ray <r...@zianet.com> wrote:
    > On Sun, 01 Mar 2009 11:47:27 -0800, kurtwheeling1965 wrote:
    > >http://www.diabetes.org/diabetes-res...etformin-isnt-

    > enough.jsp
    >
    > > (for Chris Malcolm)

    >
    > >http://care.diabetesjournals.org/cgi...stract/32/1/84

    >
    > > (excerpt)

    >
    > > What did the researchers find?
    > > Adding liraglutide to metformin provided better diabetes control than
    > > metformin alone. The liraglutide-metformin combination controlled blood
    > > glucose as well as and caused less weight gain and hypoglycemia than a
    > > combination of glimepiride and metformin. Liraglutide caused more nausea
    > > than glimepiride, but the nausea declined over time.

    >
    > I find that for me, metformin alone is not enough. Neither is exercise
    > alone or diet (low carb) alone. Matter of fact, no two of them seem to
    > suffice - but ALL THREE TOGETHER work very well


    Sometimes "It takes a village..."

    Kurt

  5. #5
    [email protected] Guest

    Default Re: When Metformin Isn't Enough

    On Mar 1, 3:19�pm, sassybklynl...@webtv.net (Loretta Eisenberg) wrote:
    > Kurt, for me adding byetta to the mix did the trick for me.
    >
    > talk about nausea, byetta caused it for a long time , hence I couldnt
    > eat, �then it stopped making me sick and my appetitite returned


    Glad to hear you finally found something that not only works, but
    keeps on working. I know you struggled for quite some time and your
    tenacity paid off.

    Kurt

  6. #6
    Jacquie Guest

    Default Re: When Metformin Isn't Enough


    <[email protected]> wrote in message
    news:[email protected]...
    > http://www.diabetes.org/diabetes-res...snt-enough.jsp
    >
    > (for Chris Malcolm)
    >
    > http://care.diabetesjournals.org/cgi...stract/32/1/84
    >
    > (excerpt)
    >
    > What did the researchers find?
    > Adding liraglutide to metformin provided better diabetes control than
    > metformin alone. The liraglutide-metformin combination controlled
    > blood glucose as well as and caused less weight gain and hypoglycemia
    > than a combination of glimepiride and metformin. Liraglutide caused
    > more nausea than glimepiride, but the nausea declined over time.
    >


    I have found lately that my numbers are not staying down on Metformin alone.
    I can have a snack before I go to bed ..maybe a couple of crackers and
    cheese...and wake up the next morning with numbers in the 145-150
    range....or not have a snack and the same thing happens. After a breakfast
    of 2 eggs and a slice of low carb toast...two hours later I could have a
    number of 180...maybe it is time for another med along with Metformin...I
    have been on it for 10 years or so...and it has always worked well except
    for lately. I couldn't tolerate Byetta...and I sure as heck don't want to be
    on anything that causes weight gain...that is a constant fight for me.
    Anybody on Januvia? I am on 1500 mg of Metformin a day. I have terrible
    nausea with 2000 mg even after a couple of months being on 2000mg. Guess my
    system doesn't want that extra 500mg.

    Jacquie


  7. #7
    W. Baker Guest

    Default Re: When Metformin Isn't Enough

    Jacquie <[email protected]> wrote:
    : I have found lately that my numbers are not staying down on Metformin alone.
    : I can have a snack before I go to bed ..maybe a couple of crackers and
    : cheese...and wake up the next morning with numbers in the 145-150
    : range....or not have a snack and the same thing happens. After a breakfast
    : of 2 eggs and a slice of low carb toast...two hours later I could have a
    : number of 180...maybe it is time for another med along with Metformin...I
    : have been on it for 10 years or so...and it has always worked well except
    : for lately. I couldn't tolerate Byetta...and I sure as heck don't want to be
    : on anything that causes weight gain...that is a constant fight for me.
    : Anybody on Januvia? I am on 1500 mg of Metformin a day. I have terrible
    : nausea with 2000 mg even after a couple of months being on 2000mg. Guess my
    : system doesn't want that extra 500mg.

    : Jacquie

    Jackie, I forget if I already asked you this. Are you on the
    extended-slow release form of Metformin? If not, try it and you may well
    be able to tolerate the 2,000mg a day.

    Wendy

  8. #8
    sanforized Guest

    Default Re: When Metformin Isn't Enough

    W. Baker wrote:
    > Jacquie <[email protected]> wrote:
    > : I have found lately that my numbers are not staying down on Metformin alone.
    > : I can have a snack before I go to bed ..maybe a couple of crackers and
    > : cheese...and wake up the next morning with numbers in the 145-150
    > : range....or not have a snack and the same thing happens. After a breakfast
    > : of 2 eggs and a slice of low carb toast...two hours later I could have a
    > : number of 180...maybe it is time for another med along with Metformin...I
    > : have been on it for 10 years or so...and it has always worked well except
    > : for lately. I couldn't tolerate Byetta...and I sure as heck don't want to be
    > : on anything that causes weight gain...that is a constant fight for me.
    > : Anybody on Januvia? I am on 1500 mg of Metformin a day. I have terrible
    > : nausea with 2000 mg even after a couple of months being on 2000mg. Guess my
    > : system doesn't want that extra 500mg.
    >
    > : Jacquie
    >
    > Jackie, I forget if I already asked you this. Are you on the
    > extended-slow release form of Metformin? If not, try it and you may well
    > be able to tolerate the 2,000mg a day.


    I went through this. If I recall correctly......XR had a release time
    not all that much greater than the regular yet at a greater (patent
    not expired) price. I split my Metformin into 2 doses a day and maintain
    1000 mg because my kidneys aren't the best.

    As a type 2 I am on insulin as well and still am fighting climbing
    A1C numbers and increasing winter weight. The trouble is that I
    will not be able to keep up the summer activity regimen of the
    past as I am aging and I can sure tell it.

  9. #9
    ray Guest

    Default Re: When Metformin Isn't Enough

    On Sun, 01 Mar 2009 19:46:46 -0800, kurtwheeling1965 wrote:

    > On Mar 1, 2:50�pm, ray <r...@zianet.com> wrote:
    >> On Sun, 01 Mar 2009 11:47:27 -0800, kurtwheeling1965 wrote:
    >> >http://www.diabetes.org/diabetes-res...hen-metformin-

    isnt-
    >> enough.jsp
    >>
    >> > (for Chris Malcolm)

    >>
    >> >http://care.diabetesjournals.org/cgi...stract/32/1/84

    >>
    >> > (excerpt)

    >>
    >> > What did the researchers find?
    >> > Adding liraglutide to metformin provided better diabetes control than
    >> > metformin alone. The liraglutide-metformin combination controlled
    >> > blood glucose as well as and caused less weight gain and hypoglycemia
    >> > than a combination of glimepiride and metformin. Liraglutide caused
    >> > more nausea than glimepiride, but the nausea declined over time.

    >>
    >> I find that for me, metformin alone is not enough. Neither is exercise
    >> alone or diet (low carb) alone. Matter of fact, no two of them seem to
    >> suffice - but ALL THREE TOGETHER work very well

    >
    > Sometimes "It takes a village..."
    >
    > Kurt


    No. It takes discipline.

  10. #10
    W. Baker Guest

    Default Re: When Metformin Isn't Enough

    sanforized <[email protected]> wrote:
    : W. Baker wrote:
    : > Jacquie <[email protected]> wrote:
    : > : I have found lately that my numbers are not staying down on Metformin alone.
    : > : I can have a snack before I go to bed ..maybe a couple of crackers and
    : > : cheese...and wake up the next morning with numbers in the 145-150
    : > : range....or not have a snack and the same thing happens. After a breakfast
    : > : of 2 eggs and a slice of low carb toast...two hours later I could have a
    : > : number of 180...maybe it is time for another med along with Metformin...I
    : > : have been on it for 10 years or so...and it has always worked well except
    : > : for lately. I couldn't tolerate Byetta...and I sure as heck don't want to be
    : > : on anything that causes weight gain...that is a constant fight for me.
    : > : Anybody on Januvia? I am on 1500 mg of Metformin a day. I have terrible
    : > : nausea with 2000 mg even after a couple of months being on 2000mg. Guess my
    : > : system doesn't want that extra 500mg.
    : >
    : > : Jacquie
    : >
    : > Jackie, I forget if I already asked you this. Are you on the
    : > extended-slow release form of Metformin? If not, try it and you may well
    : > be able to tolerate the 2,000mg a day.

    : I went through this. If I recall correctly......XR had a release time
    : not all that much greater than the regular yet at a greater (patent
    : not expired) price. I split my Metformin into 2 doses a day and maintain
    : 1000 mg because my kidneys aren't the best.

    : As a type 2 I am on insulin as well and still am fighting climbing
    : A1C numbers and increasing winter weight. The trouble is that I
    : will not be able to keep up the summer activity regimen of the
    : past as I am aging and I can sure tell it.

    We all have individual responses to meds. On the regular Metformin I was
    uable to lee the house unless I took Immodium(generic). Now, with the
    extended realease, whch I take twice a day, I no longer have this problem
    and don't have to have an immodium pill in every pocket adn handbag!
    worked spectaculerly for me, but you have to find what works for you.

    Wendy

  11. #11
    Jacquie Guest

    Default Re: When Metformin Isn't Enough

    Yes I am on the XR....I just have a funny stomach...the Hiatal Hernia
    doesn't help either.
    Jacquie
    "W. Baker" <[email protected]> wrote in message
    news:gogna0$cdf$[email protected]..
    > Jacquie <[email protected]> wrote:
    > : I have found lately that my numbers are not staying down on Metformin
    > alone.
    > : I can have a snack before I go to bed ..maybe a couple of crackers and
    > : cheese...and wake up the next morning with numbers in the 145-150
    > : range....or not have a snack and the same thing happens. After a
    > breakfast
    > : of 2 eggs and a slice of low carb toast...two hours later I could have a
    > : number of 180...maybe it is time for another med along with
    > Metformin...I
    > : have been on it for 10 years or so...and it has always worked well
    > except
    > : for lately. I couldn't tolerate Byetta...and I sure as heck don't want
    > to be
    > : on anything that causes weight gain...that is a constant fight for me.
    > : Anybody on Januvia? I am on 1500 mg of Metformin a day. I have terrible
    > : nausea with 2000 mg even after a couple of months being on 2000mg.
    > Guess my
    > : system doesn't want that extra 500mg.
    >
    > : Jacquie
    >
    > Jackie, I forget if I already asked you this. Are you on the
    > extended-slow release form of Metformin? If not, try it and you may well
    > be able to tolerate the 2,000mg a day.
    >
    > Wendy



  12. #12
    Jacquie Guest

    Default Re: When Metformin Isn't Enough

    I have tried splitting it up but the way my memory is I always forget the
    daytime dosage. It's easier for me to take everything at night because it
    has become a nighttime ritual I have arthritic knees where I can no longer
    walk a long ways....not to mention a falling arch . I look forward to the
    Summer because we have a pool and I can get some aerobic exercise in. Now
    all I do is stretching exercises. The pool temp was 75degrees F
    yesterday...still a bit to cool for me but maybe by the end of next month I
    will be able to get in. I have a friend that is 84 years young and he still
    rides his bike daily....I really admire him
    Jacquie
    "sanforized" <[email protected]> wrote in message
    news:[email protected]..
    > W. Baker wrote:
    >> Jacquie <[email protected]> wrote:
    >> : I have found lately that my numbers are not staying down on Metformin
    >> alone. : I can have a snack before I go to bed ..maybe a couple of
    >> crackers and : cheese...and wake up the next morning with numbers in the
    >> 145-150 : range....or not have a snack and the same thing happens. After
    >> a breakfast : of 2 eggs and a slice of low carb toast...two hours later I
    >> could have a : number of 180...maybe it is time for another med along
    >> with Metformin...I : have been on it for 10 years or so...and it has
    >> always worked well except : for lately. I couldn't tolerate Byetta...and
    >> I sure as heck don't want to be : on anything that causes weight
    >> gain...that is a constant fight for me. : Anybody on Januvia? I am on
    >> 1500 mg of Metformin a day. I have terrible : nausea with 2000 mg even
    >> after a couple of months being on 2000mg. Guess my : system doesn't want
    >> that extra 500mg.
    >>
    >> : Jacquie Jackie, I forget if I already asked you this. Are you on the
    >> extended-slow release form of Metformin? If not, try it and you may well
    >> be able to tolerate the 2,000mg a day.

    >
    > I went through this. If I recall correctly......XR had a release time
    > not all that much greater than the regular yet at a greater (patent
    > not expired) price. I split my Metformin into 2 doses a day and maintain
    > 1000 mg because my kidneys aren't the best.
    >
    > As a type 2 I am on insulin as well and still am fighting climbing
    > A1C numbers and increasing winter weight. The trouble is that I
    > will not be able to keep up the summer activity regimen of the
    > past as I am aging and I can sure tell it.



  13. #13
    Jacquie Guest

    Default Re: When Metformin Isn't Enough




    "W. Baker" <[email protected]> wrote in message
    news:goh341$1nt$[email protected]..
    > sanforized <[email protected]> wrote:
    > : W. Baker wrote:
    > : > Jacquie <[email protected]> wrote:
    > : > : I have found lately that my numbers are not staying down on
    > Metformin alone.
    > : > : I can have a snack before I go to bed ..maybe a couple of crackers
    > and
    > : > : cheese...and wake up the next morning with numbers in the 145-150
    > : > : range....or not have a snack and the same thing happens. After a
    > breakfast
    > : > : of 2 eggs and a slice of low carb toast...two hours later I could
    > have a
    > : > : number of 180...maybe it is time for another med along with
    > Metformin...I
    > : > : have been on it for 10 years or so...and it has always worked well
    > except
    > : > : for lately. I couldn't tolerate Byetta...and I sure as heck don't
    > want to be
    > : > : on anything that causes weight gain...that is a constant fight for
    > me.
    > : > : Anybody on Januvia? I am on 1500 mg of Metformin a day. I have
    > terrible
    > : > : nausea with 2000 mg even after a couple of months being on 2000mg.
    > Guess my
    > : > : system doesn't want that extra 500mg.
    > : >
    > : > : Jacquie
    > : >
    > : > Jackie, I forget if I already asked you this. Are you on the
    > : > extended-slow release form of Metformin? If not, try it and you may
    > well
    > : > be able to tolerate the 2,000mg a day.
    >
    > : I went through this. If I recall correctly......XR had a release time
    > : not all that much greater than the regular yet at a greater (patent
    > : not expired) price. I split my Metformin into 2 doses a day and maintain
    > : 1000 mg because my kidneys aren't the best.
    >
    > : As a type 2 I am on insulin as well and still am fighting climbing
    > : A1C numbers and increasing winter weight. The trouble is that I
    > : will not be able to keep up the summer activity regimen of the
    > : past as I am aging and I can sure tell it.
    >
    > We all have individual responses to meds. On the regular Metformin I was
    > uable to lee the house unless I took Immodium(generic). Now, with the
    > extended realease, whch I take twice a day, I no longer have this problem
    > and don't have to have an immodium pill in every pocket adn handbag!
    > worked spectaculerly for me, but you have to find what works for you.
    >
    > Wendy


    LOL, I know what you mean Wendy. I still keep the Imodium in my purse just
    in case. When I was on the regular Metformin I never left the house without
    taking at least two Imodium before we left...I wasn't going to wait for an
    attack to hit me and then take a pill...besides when you live in the middle
    of no where bathrooms are few and far between...LOL. I like Metformin but
    am wondering if maybe I need something else to keep my numbers down. I never
    get really high numbers like in the three hundreds...I have had a 200 a
    couple of times , not often though. I like to stay in the 90-100 range . We
    will see what my next A1C shows and I plan on discussing this with my Dr.
    Jacquie


  14. #14
    Alan S Guest

    Default Re: When Metformin Isn't Enough

    On Mon, 02 Mar 2009 08:21:52 -0600, sanforized
    <[email protected]> wrote:

    >
    >As a type 2 I am on insulin as well and still am fighting climbing
    >A1C numbers and increasing winter weight. The trouble is that I
    >will not be able to keep up the summer activity regimen of the
    >past as I am aging and I can sure tell it.


    You've mentioned meds changes, insulin and sleep problems
    but you haven't mentioned any dietary changes. What dietary
    regimen do you follow?

    Have you read this:
    http://www.alt-support-diabetes.org/NewlyDiagnosed.htm
    or this
    http://loraldiabetes.blogspot.com/20...ew-adjust.html
    ?


    Cheers, Alan, T2, Australia.
    --
    d&e, metformin 2000 mg
    Everything in Moderation - Except Laughter.
    http://loraldiabetes.blogspot.com (I Ate Nothing! Why Are My BGs high?)
    http://loraltravel.blogspot.com (To Delhi)

  15. #15
    W. Baker Guest

    Default Re: When Metformin Isn't Enough

    Jacquie <[email protected]> wrote:
    : I have tried splitting it up but the way my memory is I always forget the
    : daytime dosage. It's easier for me to take everything at night because it
    : has become a nighttime ritual I have arthritic knees where I can no longer
    : walk a long ways....not to mention a falling arch . I look forward to the
    : Summer because we have a pool and I can get some aerobic exercise in. Now
    : all I do is stretching exercises. The pool temp was 75degrees F
    : yesterday...still a bit to cool for me but maybe by the end of next month I
    : will be able to get in. I have a friend that is 84 years young and he still
    : rides his bike daily....I really admire him
    : Jacquie

    Jacquie,

    I have a wooden paddle that sits on my dining table with all y meds on
    it. In this way I can take y morning meds at breakfast and my dinner ones
    at -guess when! dinner:-) It helps me to remember as they sit right in
    fron of my place. My night pilss(11, including doubles) are in one of
    those weekly pill containers and sit near the bthroom sink. they are too
    many to open all 8 bottles nightly! Mostly calcium, folic acid, B 6 and
    12, amaryl, Lipitor and neurontin fo rmy back. So far I have not
    forgotton to take them. My husband, with his forgettery, has a weekly pil
    container on the dining table and I then can remember to remind him:-)

    Wendy

  16. #16
    Cheri Guest

    Default Re: When Metformin Isn't Enough

    "W. Baker" <[email protected]> wrote in message
    news:gohgcp$22g$[email protected]..

    > forgotton to take them. My husband, with his forgettery, has a weekly pil
    > container on the dining table and I then can remember to remind him:-)
    >
    > Wendy


    I love the word "forgettery" Wendy. I have that a lot lately, but I am going
    to remember that word. :-)

    Cheri



  17. #17
    Nicky Guest

    Default Re: When Metformin Isn't Enough

    On Mon, 2 Mar 2009 11:43:00 -0700, "Jacquie"
    <[email protected]> wrote:

    >I look forward to the
    >Summer because we have a pool and I can get some aerobic exercise in. Now
    >all I do is stretching exercises.

    Could you add some light resistance exercises, Jacquie, or would the
    hernia object? - I'm thinking that a few more muscles might make all
    the difference with bg control...

    Nicky.
    T2 dx 05/04 + underactive thyroid
    D&E, 100ug thyroxine
    Last A1c 5.3% BMI 25

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