Dietary glycemic load, whole grains, and systemic inflammation in
diabetes: the epidemiological evidence.
Qi L, Hu FB
Curr Opin Lipidol. 2007 Feb ; 18(1): 3-8
PURPOSE OF REVIEW: The aim of this article is to present recent
findings from epidemiological studies on the effects of dietary
glycemic load and whole grain foods on systemic inflammation in
diabetic patients and to postulate potential mechanisms. RECENT
FINDINGS: Diets low in glycemic index/load or high in whole grain
products have been associated with decreased concentrations of
inflammatory markers and increased adiponectin levels among diabetic
patients. These associations appear to be independent of body weight,
glycemic control, and other cardiovascular risk factors. The protective
effects of low glycemic load and high whole grains on systemic
inflammation may be explained, in part, by reduction in
hyperglycemia-induced overproduction of oxidative stress and by
amelioration in
insulin resistance, adiposity, dyslipidemia, and
hypertension. SUMMARY: Diets low in glycemic load and high in whole
grains may have a protective effect against systemic inflammation in
diabetic patients. Such diets can be recommended to diabetic patients
for the prevention of cardiovascular complications.
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