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  #1  
Old 01-14-2007, 02:23 AM
FurPaw
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Default Mouth ulcer from a bisphosphonate

I don't know if anyone here is taking an anti-osteoporosis drug.
If so, this article can serve as a warning against holding the
tablets in your mouth:
http://content.nejm.org/cgi/content/full/355/22/e25

The patient, who wore dentures, held the fosamax tablet behind
her upper denture for a while in order to help her swallow it.
She got an ulceration in her mouth as a result.

FurPaw
--
Better dead than Red.

To reply, unleash the dog.
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  #2  
Old 01-14-2007, 02:23 AM
foggydoggy
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Default Re: Mouth ulcer from a bisphosphonate


"FurPaw" <furrealpawdog@gmail.com> wrote in message
news:NoqdndMsi5g2lvPYnZ2dnUVZ_q-dnZ2d@comcast.com...
>I don't know if anyone here is taking an anti-osteoporosis drug. If so,
>this article can serve as a warning against holding the tablets in your
>mouth:
> http://content.nejm.org/cgi/content/full/355/22/e25
>
> The patient, who wore dentures, held the fosamax tablet behind her upper
> denture for a while in order to help her swallow it. She got an ulceration
> in her mouth as a result.
>
> FurPaw
> --


One has to be careful with the osteoporosis meds. Along with the heartburn
problems there is now concern with potential osteonecrosis of the jawbone.
Prevention to the best of your ability is the key to staying off these
meds.Calcium & magnesium supplements along with vitamen D to maximize
absorption, lots of regular weight bearing excercise, lifting weights,
stress management to keep cortisol levels at normal levels as high cortisol
decreases bone density.

I think the key is lifelong activity.Osteoporosis is partly a disease of
affluence: too much sedentary living, sitting at deskjobs, vehicles instead
of walking, and processed food.

Roseanne


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  #3  
Old 01-14-2007, 02:23 AM
Chakolate
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Default Re: Mouth ulcer from a bisphosphonate

"foggydoggy" <foggydoggy@cogeco.ca> wrote in
news:RJtbh.18691$tP.9242@read2.cgocable.net:

> I think the key is lifelong activity.Osteoporosis is partly a disease
> of affluence: too much sedentary living, sitting at deskjobs, vehicles
> instead of walking, and processed food.
>


Unhappily (for me) lifelong activity is the key to far too much. I've
always been sedentary, and I suspect it's going to be my undoing in the
end.

At least I have a set of weights and while watching tv I use them. Sort
of a Couch Potato Triathlon.

Chak

--
I've learned that whenever I decide something with an open heart, I
usually make the right decision.
--Maya Angelou
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  #4  
Old 01-14-2007, 02:23 AM
Chris Malcolm
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Default Re: Mouth ulcer from a bisphosphonate

Chakolate <chakolateDeathToSpammers@gmail.com> wrote:
> "foggydoggy" <foggydoggy@cogeco.ca> wrote in
> news:RJtbh.18691$tP.9242@read2.cgocable.net:


>> I think the key is lifelong activity.Osteoporosis is partly a disease
>> of affluence: too much sedentary living, sitting at deskjobs, vehicles
>> instead of walking, and processed food.
>>


> Unhappily (for me) lifelong activity is the key to far too much. I've
> always been sedentary, and I suspect it's going to be my undoing in the
> end.


> At least I have a set of weights and while watching tv I use them. Sort
> of a Couch Potato Triathlon.


I've started doing that too. I injured my elbow tendons over a year
ago by an over amibitious exercise programme, kind of like tennis or
golf elbow. The damage is healing *so* slowly I sometimes think it
isn't. I decided to try very high reps of all sorts of lifting and
twisting and reaching with very light weights. When I find I can keep
going for a whole half hour TV programme without fatigue I raise the
weight a little bit. I've just raised them the first notch up to a bit
less than 4lbs.

Sometimes I lie on my back on the floor lifting the weights around
while watching TV, while Small Cat sits on my chest doing neck exercises
by following the weights around with her head :-)

I combine the exercise with lots of before and after massage of the
painful upper forearm and elbow area.

It's the first thing I've found which really seems to be working in
the sense of recovering from the injury. It's now very much harder to
hurt my arms/elbows than it used to be, and the stabbing pains I used
to get sometimes lifting something as simple as a mug of tea have
entirely gone away.

--
Chris Malcolm cam@infirmatics.ed.ac.uk DoD #205
IPAB, Informatics, JCMB, King's Buildings, Edinburgh, EH9 3JZ, UK
[http://www.dai.ed.ac.uk/homes/cam/]

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  #5  
Old 01-14-2007, 02:23 AM
Mickey
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Default Re: Mouth ulcer from a bisphosphonate

i take it but i have no problems swallowing pills.

thanks for the article furry.

mickey

"FurPaw" <furrealpawdog@gmail.com> wrote in message
news:NoqdndMsi5g2lvPYnZ2dnUVZ_q-dnZ2d@comcast.com...
> I don't know if anyone here is taking an anti-osteoporosis drug.
> If so, this article can serve as a warning against holding the
> tablets in your mouth:
> http://content.nejm.org/cgi/content/full/355/22/e25
>
> The patient, who wore dentures, held the fosamax tablet behind
> her upper denture for a while in order to help her swallow it.
> She got an ulceration in her mouth as a result.
>
> FurPaw
> --
> Better dead than Red.
>
> To reply, unleash the dog.



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  #6  
Old 01-14-2007, 02:23 AM
Chakolate
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Default Re: Mouth ulcer from a bisphosphonate

Chris Malcolm <cam@holyrood.ed.ac.uk> wrote in news:4t7tr8Fvr49uU1
@mid.individual.net:

> It's the first thing I've found which really seems to be working in
> the sense of recovering from the injury. It's now very much harder to
> hurt my arms/elbows than it used to be, and the stabbing pains I used
> to get sometimes lifting something as simple as a mug of tea have
> entirely gone away.


That's good to hear. I don't have any such ailments to recover from, but
I do notice that when I keep up the weights and the leg machine (also in
front of the tube) everyday things in general are easier. Getting in and
out of the car, lifting Tristan or Sophie, lugging groceries up the
stairs, all seem a bit less weighty.

Chak

--
I've learned that whenever I decide something with an open heart, I
usually make the right decision.
--Maya Angelou
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  #7  
Old 01-14-2007, 02:23 AM
Chris Malcolm
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Posts: n/a
Default Re: Mouth ulcer from a bisphosphonate

Chakolate <chakolateDeathToSpammers@gmail.com> wrote:
> Chris Malcolm <cam@holyrood.ed.ac.uk> wrote in news:4t7tr8Fvr49uU1
> @mid.individual.net:


>> It's the first thing I've found which really seems to be working in
>> the sense of recovering from the injury. It's now very much harder to
>> hurt my arms/elbows than it used to be, and the stabbing pains I used
>> to get sometimes lifting something as simple as a mug of tea have
>> entirely gone away.


> That's good to hear. I don't have any such ailments to recover from, but
> I do notice that when I keep up the weights and the leg machine (also in
> front of the tube) everyday things in general are easier. Getting in and
> out of the car, lifting Tristan or Sophie, lugging groceries up the
> stairs, all seem a bit less weighty.


Obviously the body has some threshold of muscle strain beyond which it
thinks the muscle isn't strong enough and needs to grow a bit. It also
shrinks muscles which you don't use. So your muscle size is actually a
dynamic balance between the body's eating up what you don't use, and
being reminded of how much muscle you need by what you do with it.

The threshold of how much muscle you add in response to how much strain
is controlled by hormones. Hence the taking of hormones by body
builders.

As we age the levels of these hormones drop. So as we age the size of
muscle our everyday activities give us drops, and unusual exertions
become harder. This starts off a vicious circle, because we then start
avoiding those unusually strenuous activities which have become
harder, and so our muscles get less worked than they used to, and get
weaker still.

I suspect that when we're young these thresholds are set so that an
activity level of X actually produces muscles capable of say 150% of
X. In other words, lifting something weighing X every day will give
you muscles which can actually lift half as much again without much
struggle.

I suspect that as we age that threshold eventually drops below
replacement point, so that lifting X every day only gives you muscles
capable of lifting 99% of X. So with the passage of time lifting X
becomes harder and harder until you give up doing it.

Hence, IMHO, the importance of exercising as you age. If you want to
go on being able to lift that shopping bag, open that jar, or indeed
get up out of that armchair, you're going to have to push yourself
regularly to do something stronger than that in order to be able to
keep on doing that easily.

Incidentally the same thing is true of bones. Our bodies are always
leaching away those bits of our bones that aren't being used
(stressed), and growing bone back in those places where stress is
felt, so like muscle, the strength of our bones is a dynamic balance
between continuous processes of loss and replacement. There is an
added problem with bones, which is that what stresses them is not only
the forces exerted on them by muscles, but shock loads, impact. A
tennis player or boxer will develop stronger bones than a weight
lifter with the same size of muscles because of the larger shock
loads.

As we age we bruise and strain more easily, so not only do we use our
muscles less, but we are also also more careful to avoid sudden
impacts. We don't like bumping into things, we get more scared of
falling over, we stop doing the odd bit of running or jumping down off
low things so our legs and spines get less impact walloping. So our
bones are subjected to a double loss of stress. Not only are they
subject to reducing muscular loads, but in addition reducing impact
loads.

In other words, use it or lose it becomes increasingly important as we
age.

--
Chris Malcolm cam@infirmatics.ed.ac.uk DoD #205
IPAB, Informatics, JCMB, King's Buildings, Edinburgh, EH9 3JZ, UK
[http://www.dai.ed.ac.uk/homes/cam/]

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