BL 1020

hello,
did anyone heard about the future new drug BL 1020 ?
what do you think of it ?

On 15 aug, 11:45, mouhahaha <mouhah...@free.com> wrote:
> hello,
> did anyone heard about the future new drug BL 1020 ?
> what do you think of it ?

I think it is a drug with a twist

Le Wed, 15 Aug 2007 02:59:35 -0700, Adamski_Rasputin a écrit:

what do you mean ? (my english is not excellent)

it is said to be a cognitive drug, with less problems than zyprexa,
abilify etc

> I think it is a drug with a twist

On 15 aug, 13:16, archybald <d...@yahoo.com> wrote:
> Le Wed, 15 Aug 2007 02:59:35 -0700, Adamski_Rasputin a écrit:
>
> what do you mean ? (my english is not excellent)
>
> it is said to be a cognitive drug, with less problems than zyprexa,
> abilify etc
>
>
>
> > I think it is a drug with a twist- Tekst uit oorspronkelijk bericht niet weergeven -
>
> - Tekst uit oorspronkelijk bericht weergeven -

It was a pun. Nothing wrong with the drug, so far, it is in fase II
trials
I hope it will make it to the market.

Berty

i hope too
if it is now in phase 2, how many phase are there ?
when will the test will be finished according to you ?

It blocks dopamine and increases GABA and has virtually no metabolic
or movement disorder side effects. It has been shown to be effective
and is in Phase II trials. More data from the Phase II trials will be
released later this year. It is not expected to hit the market for
another few years atleast. If it doesn't pass Phase III it won't make
the market at all.

~Cory

On 15 aug, 15:52, mouhahaha <mouhah...@free.com> wrote:
> i hope too
> if it is now in phase 2, how many phase are there ?
> when will the test will be finished according to you ?

In another thread called Phase II trials there is
a link to wikipedia where they explained the trials for medications.

thansk for the answers
isn't there a paradox ? bl1020 is said to help in cognitive functions
because it increase gaba, but benzodiazepines also increase gaba and are
catastrophic for cognitive function (memory...etc) and dangerous with
alcohol....

Forgive me for not googling or wiki-ing, but does the GABA increase do
anything? Is it a negative symptom thing or just a side effect?


<coryschulz@gmail.com> wrote in message
news:1187187593.344867.207080@i38g2000prf.googlegr oups.com...
> It blocks dopamine and increases GABA and has virtually no metabolic
> or movement disorder side effects. It has been shown to be effective
> and is in Phase II trials. More data from the Phase II trials will be
> released later this year. It is not expected to hit the market for
> another few years atleast. If it doesn't pass Phase III it won't make
> the market at all.
>
> ~Cory
>

GABA is an inhibitory neurotransmitter in the brain, and very directly
blocks dopamine and epinephrine and I also believe it partially blocks
serotonin too, but sometimes it can increase serotonin slightly. It
can also act as a minor stimulant in some parts of the brain, as it
has been known to bring people out of a coma that they've been in for
years. Date rape increases GABA and the sleeping pills on the market
(Sonata, Ambien) increase GABA as well. Benzos (Xanax, Valium) also
increase GABA and are very addictive and you quickly build a tolerance
to them. Same with the sleeping pills, you should not take them every
night (like I sometimes do).

The side effects of increasing GABA are that you feel tired and
relaxed, they lower the activity in your amygdala, which then makes
you less paranoid and lowers your flight or fight response. It also
weakens your memory, especially short term memory, and makes you feel
very dreamy. Many people abuse these drugs and take them
recreationally because they feel slightly euphoric and relaxing.

To be honest, this is the first drug of its kinda that both blocks
dopamine and increases GABA and I have no idea what it will feel like,
but I do believe this is a completely novel way of stabilizing
dopamine and that it makes sense that it will have minor side effects,
and it should be just as effective as the drugs that are out today. It
is only in Phase II trials, so we will see what happens once it's been
in Phase III for a while. Until then we all have to play the waiting
game and hope we can manage until these newer drugs make their way to
our pharmacies.

http://www.schizophrenia.com/sznews/...es/005386.html
http://www.biolinerx.com/NewsPress.asp

PS - There are 5 Phases starting from 0 and going to 4.
http://en.wikipedia.org/wiki/Clinical_trial
Phase 3 is considered the most important and most watched.