<<sniip>>
antioxidants might be an effective therapeutic approach to partially
alleviate or prevent the symptoms of schizophrenia
<<snip>>
J Zhejiang Univ Sci B. 2006 Dec.;7(12):981-986. Links
Imbalanced free radicals and antioxidant defense systems in
schizophrenia: A comparative study.Li HC, Chen QZ, Ma Y, Zhou JF.
Department of Psychiatry, the Second Affiliated Hospital, School of
Medicine, Zhejiang University, Hangzhou 310009, China;
zrjsk@zju.edu.cn.
Objective: To examine changes of blood oxidative-antiovidative level in
schizophrenic patients and its relationship with clinical symptoms.
Methods: Forty-six Chinese patients met DSM-IV (Diagnostic and
Statistical Manual of Mental Disorders-IV) criteria for schizophrenia
and fifty age- and sex-matched healthy controls were enrolled in the
present study. Baseline psychiatric symptom severity was assessed with
brief psychiatric rating scale, positive and negative syndrome scale on
the blood draw day. Fresh blood samples were collected to measure
levels of nitric oxide and lipid peroxide in plasma as well as
activities of superoxide dismutase, catalase and glutathione peroxidase
in red blood cells by spectrophotometric assays simultaneously.
Results: Comparison of the biochemical parameters indicated that the
level of nitric oxide and lipid peroxide increased in patient group,
which represented a positive correlation with positive scale scores;
while the activities of three critical enzymes decreased and showed a
negative linear correlation. Conclusion: This study showed that there
are dysregulation of free radical metabolism and poor activities of the
antioxidant defense systems in schizophrenic patients. Excess free
radicals formation may play a critical role in the etiology of
schizophrenia. Using antioxidants might be an effective therapeutic
approach to partially alleviate or prevent the symptoms of
schizophrenia.
PMID: 17111467 [PubMed - as supplied by publisher]
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