A preliminary study of the levels of testis oxidative stress parameters
after MK-801-induced experimental psychosis model: Protective effects
of CAPE.
Ozyurt B, Parlaktas BS, Ozyurt H, Aslan H, Ekici F, Atis O
Toxicology. 2006 Nov 15;
We evaluated the effects of caffeic acid phenethyl ester (CAPE) on
antioxidant enzyme levels and histopathologic changes in dizocilpine
(MK-801) induced schizophrenic rat testis. A total of 30 adult male
Wistar-Albino rats were divided into three groups. Group-I was used as
control. Rats in the Group-II were intraperitoneally injected with
MK-801, whereas those in Group-III were intraperitoneally injected with
CAPE in addition to MK-801. The testes were collected for biochemical
and histopathological examinations. Antioxidant enzyme activities,
malondialdehyde, protein carbonyl and nitric oxide levels in testicular
tissues were analyzed with spectrophotometric methods. Induction of
schizophrenia resulted in a significant oxidative stress by increasing
the levels of antioxidant enzymes. Tissue malondialdehyde and protein
carbonyl levels were also increased. Treatment with CAPE led to
significant decrease in oxidative injury. Administration of CAPE
reduced the detrimental histopathologic changes caused by MK-801. The
results showed that experimentally induced schizophrenia caused
oxidative stress in testes of rats and treatment with CAPE reduced
these harmful effects.
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10.1016/j.tox.2006.11.047
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<<sniip>>
antioxidants might be an effective therapeutic approach to partially
alleviate or prevent the symptoms of schizophrenia
<<snip>>
J Zhejiang Univ Sci B. 2006 Dec.;7(12):981-986. Links
Imbalanced free radicals and antioxidant defense systems in
schizophrenia: A comparative study.Li HC, Chen QZ, Ma Y, Zhou JF.
Department of Psychiatry, the Second Affiliated Hospital, School of
Medicine, Zhejiang University, Hangzhou 310009, China;
z...@zju.edu.cn.
Objective: To examine changes of blood oxidative-antiovidative level in
schizophrenic patients and its relationship with clinical symptoms.
Methods: Forty-six Chinese patients met DSM-IV (Diagnostic and
Statistical Manual of Mental Disorders-IV) criteria for schizophrenia
and fifty age- and sex-matched healthy controls were enrolled in the
present study. Baseline psychiatric symptom severity was assessed with
brief psychiatric rating scale, positive and negative syndrome scale on
the blood draw day. Fresh blood samples were collected to measure
levels of nitric oxide and lipid peroxide in plasma as well as
activities of superoxide dismutase, catalase and glutathione peroxidase
in red blood cells by spectrophotometric assays simultaneously.
Results: Comparison of the biochemical parameters indicated that the
level of nitric oxide and lipid peroxide increased in patient group,
which represented a positive correlation with positive scale scores;
while the activities of three critical enzymes decreased and showed a
negative linear correlation. Conclusion: This study showed that there
are dysregulation of free radical metabolism and poor activities of the
antioxidant defense systems in schizophrenic patients. Excess free
radicals formation may play a critical role in the etiology of
schizophrenia. Using antioxidants might be an effective therapeutic
approach to partially alleviate or prevent the symptoms of
schizophrenia.
PMID: 17111467 [PubMed - as supplied by publisher]
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Oxidative stress induced schizophrenia 
Linear Mode
