"Red wine and red grapes contain a chemical, called resveratrol, that
can offset some of the effects of gluttony, say researchers from the
National Institute on Aging, Harvard Medical School, USA. Resveratrol
does not seem to be able to get rid of the obesity, but it can lower
glucose levels, help your liver and improve your heart." From:
http://www.emaxhealth.com/1/8154.html
"Fat-related deaths dropped 31 percent for obese mice on the
supplement, compared to untreated obese mice - and the treated mice
also lived longer than expected and were more energetic despite their
extra weight." From:
http://www.masslive.com/editorials/r...090.xml&coll=1
aka
http://tinyurl.com/yawa8j
The recent U.S. News and World Report carries a one-page article on the
substance as well.
"In the study, one group of year-old lab mice-middle age for these
animals-were put on a high-calorie, high-fat diet, and dosed with
resveratrol, the chemical in red grape skins. Another group got the
same diet but no resveratrol, and a third group got an ordinary diet
and no resveratrol. The overfed mice soon ballooned to obesity, and the
fat mice that did not also get resveratrol began to die at an
accelerated rate.
The tubby mice on resveratrol, however, fared far better. Glucose and
insulin in their blood, which at high concentrations foretell diabetes
in human beings, were at much lower levels than in the fat
no-resveratrol mice. And they kept on going like the Energizer bunny.
More than a year after the experiment began, their death rate was about
the same as for the svelte mice on an ordinary diet. The resveratrol,
says lead coauthor David Sinclair, a Harvard Medical School molecular
biologist, had reversed almost all of the genetic paths that lead to
aging. "I try not to overpromise, but the data do look pretty
spectacular," says Sinclair. "They surprised me."
To get an amount of resveratrol equivalent to what the mice received
would require a person to guzzle hundreds of glasses of red wine a day.
It would be feasible, however, to concoct pills that would deliver the
needed dose without having to swallow scores of them. Sirtris
Pharmaceuticals, which Sinclair cofounded, hopes to announce within six
months or so a different chemical that acts like resveratrol but is
1,000 times more potent.
The possibility of life-extending pills that bring new hope to those
with killer diseases has made eyes snap open in labs that are
investigating the genetics of metabolism. But "fuzzy mice are not
humans," cautions Andrew Greenberg, director of the obesity and
metabolism laboratory at Tufts University in Boston. "This is
provocative and exciting, but we're a long way from humans. We need
much more safety information." Some of that may come from a safety
study underway at Sirtris of 90 people with diabetes who are getting
resveratrol. Results from that study will be available by the middle of
next year." From:
http://www.usnews.com/usnews/health/...2antiaging.htm aka
http://tinyurl.com/uhxu3
--
Curt
Resveratrol 
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