Reproductive Failure and Oxidation

"Diet, antioxidants, and oxidative stress"

Oxidative stress and antioxidants: exposure and impact on female
fertility.
Ruder EH, Hartman TJ, Blumberg J, Goldman MB
Hum Reprod Update 2008 Jun 4.


BACKGROUND
Reproductive failure is a significant public health concern. Although
relatively little is known about factors affecting fertility and
early
pregnancy loss, a growing body of literature suggests that
environmental and lifestyle factors play an important role. There is
sufficient evidence to hypothesize that diet, particularly its
constituent antioxidants, and oxidative stress (OS) may influence the
timing and maintenance of a viable pregnancy. We hypothesize that
conditions leading to OS in the female affect time-to-pregnancy and
early pregnancy loss.
METHODS
We review the epidemiology of female infertility related to
antioxidant defenses and oxidation and examine potential sources of
OS
from the ovarian germ cell through the stages of human pregnancy and
pregnancy complications related to infertility. Articles were
identified through a search of the PubMed database.
RESULTS
Female OS is a likely mediator of conception and threshold levels for
OS exist, dependent on anatomic location and stage of preconception.
CONCLUSIONS
Prospective pregnancy studies with dietary assessment and collection
of biological samples prior to conception with endpoints of time-to-
pregnancy and early pregnancy loss are needed.


Human reproduction update [Hum Reprod Update]
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