Prostate-specific antigen (PSA) is a sensitive measure of treatment outcome after radiotherapy (RT) for prostate cancer. Unlike after radical prostatectomy, when PSA should be undetectable after treatment, the PSA level after RT falls slowly and may intermittently increase over a number of years. This may be due to PSA release from partially damaged normal prostatic epithelium and/or the long time it may take for lethally damaged cancer cells to die and stop producing PSA


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