Smoking Increases Potential For Metastatic Pancreatic Cancer

[betharia]

Smoking has once again been implicated in the development of advanced cancer. Exposure to nicotine by way of cigarette smoking may increase the likelihood that pancreatic ductal adenocarcinoma will become metastatic. The culprit behind the increased metastasis potential appears to be an isoform (variant type) of a protein called osteopontin.

Nicotine promotes the expression osteopontin, and high levels of osteopontin have been reported in pancreatic ductal carcinoma (PDA). Pancreatic cancer is the fourth-leading cause of cancer death in the country, taking 34,000 lives a year. Only four percent of individuals with pancreatic cancer live for five years after diagnosis.


Regards,

Betharia

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